◇ 2025年10月10日（金）加齢研セミナーのご案内
| 日時： | 2025年10月10日（金）13時～ |
| 場所： | 加齢医学研究所 実験研究棟7階 セミナー室1 |
| 演題： | The Precision of Mistakes: Dynamic mRNA Translation Fidelity in Development and Disease |
| 講師： | 藤井 耕太郎 |
| 所属： | フロリダ大学分子遺伝学・微生物学科 神経遺伝学センター |
| 要旨： | A key question in gene regulation is how information encoded in the genome is expressed with high fidelity and precision to enable cells to adapt to their environment. By developing the first transgenic mouse model monitoring mRNA translation errors in vivo, we delineated the first spatiotemporal landscape of mRNA translation fidelity, indicating brain and muscle tissues with the highest fidelity, which was gradually established across embryonic development. Using brain organoids, we further revealed a significant impact of increasing translation errors on neuron differentiation. We also discovered the regulatory principle of translation fidelity for each transcript through codon optimality. Given the impact of translation errors for protein homeostasis and immune activation through error-containing peptide presentation, we will further discuss the hidden roles of translation fidelity for human health. |
| 担当・連絡先： | 河岡 慎平（生体情報解析分野・内線8568） |