Institute of Development, Aging and Cancer, Tohoku University

4-1 Seiryocho, Aobaku, Sendai 980-8575, Japan

Phone: +(81) 22-717-8496

©Institute of Development, Aging and Cancer, Tohoku University
Greeting & Mission

Health and Longevity through SMART-AGING.Screenshot (99)

IDAC is Japan's Center for Smart-Aging Research. We are a unique institute that is part of Tohoku University and we are affiliated with other national universities that also promote aging sciences.


It is a well-known fact that Japan’s population is aging faster than any other country in the world, and the need for aging research is becoming greater each day. Currently, the elderly make up more than 25% of the population, and in addition to the decline in birthrate, there is also a decline in the working population. In order to maintain a healthy society, it is clear that urgent measures must be taken to support an aging population.


The purpose of our institute is to shed light on the basic mechanisms of aging and to control age-related diseases, such as dementia and intractable cancers. To achieve our goals, we promote research under 3 main groups: (1) molecular mechanisms of aging and the self defense system, (2) molecular mechanism of carcinogenesis and cancer growth, and (3) brain maturation and aging. IDAC is one of the very few research institutes in the world that manages comprehensive multi-hierarchical medical research to focus on the complex mechanism of aging, by methods ranging from studying genes and cells using molecular biology techniques to directly studying people.


Specifically, our ultimate goal is to realize “smart-aging”, which refers to the development and maturation of individual abilities as one gets older, where everyone can welcome old age with liveliness and continue to be an active part of society. To make this possible, our goal is to provide medical support and policies as well as becoming a leading research center by showing the world that we can effectively manage a super-aging society. As time passes, it is critical for individuals and the population as a whole to remain healthy and continue to have the vitality for growth and wisdom.


We call this approach “SMART-AGING”.


-Ryuta KAWASHIMA, MD, Director of IDAC

Notable Alumni

IDAC's Alumni of the Month: Professor Taizo Kumagai, founder of IDAC Screenshot (108)

July 19, 1880 - February 19, 1962


Scientist and Doctor of Internal Medicine


President, Tohoku University


Director and Founder, the Research Institute for Tuberculosis and Leprosy


Advisor, Chiba Institute of Technology


Awarded 2nd place for the Order of the Rising Sun


Professor Kumagai was born and raised in Shiojiri, Nagano. After earning his doctorate in Internal Medicine from the Tohoku Imperial University School of Medicine, he attended the University of Berlin, Germany, from 1911-1913 to study immunology, experimental therapeutics, and medical chemistry. After returning to Japan, he began his research on insulin usage to combat diabetes and tuberculosis, especially with BCG. Shortly thereafter, he founded the Research Institute for Tuberculosis and Cancer, which is known today as IDAC.

History of IDAC

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The Research Institute for Tuberculosis and Cancer (formerly the Research Institute for Tuberculosis and Leprosy), was founded in 1941 by the late professor Taizo KUMAGAI as its director. At the time the Institute was established, it was the second Research Institute of Tohoku University with the purpose of overcoming leprosy and tuberculosis, with departments in three different disciplines: Internal Medicine, Leprosy and Pathological Anatomy.


In 1944, three more departments were added, namely Bacteriology, Biochemistry and Pharmacology. A few years shortly thereafter, the Departments of Surgery and Pediatrics were added in 1950 and 1953. Since then, the area of research has been widened to cover both fundamental and clinical oncology. The practical knowledge and expertise acquired during almost two decades of tuberculosis research was then applied to the study of cancer. As a result, the Department of Lung Cancer was established in 1958 and the Department of Cancer Chemotherapy in 1962.


After several years of in-depth research, an informal committee of professors from the Institute declared a new ambitious program on cancer research in August 1966. Since then, a number of cancer research projects have been subsidized by the Ministry of Education, Science, Sports and Culture, together with other Ministries of the Japanese Government. Subsequently, the Department of Radiology was established in 1967 and the Department of Clinical Cancer Chemotherapy in 1969.


Due to a growth in research facilities and staff, the Institute took another great leap forward in July 1977, when it moved from the Hirose-machi area to its present site located in Seiryo-machi. During the transition, the Department of Leprosy was replaced by the Department of Immunology, and the Department of Microbiology (formerly the Department of Bacteriology), was reorganized as the Department of Cell Biology. Two years later, the Department of Medical Engineering and Cardiology was established in 1979.


The Institute’s long history was marked by another milestone when the Tumor Cell Repository attached to the Institute was inaugurated in 1984 in order to meet the demand of researchers throughout Japan and the world. By this time, the Institute comprised of thirteen Departments, a Cancer Cell Repository, an Animal Laboratory for Tumor Research, and a Radioisotope Laboratory. Almost a decade later in 1993, the establishment was renamed as the Institute of Development, Aging and Cancer (IDAC) to reflect its commitment to Smart-Aging research. At this point in IDAC’s modest history, the Institute consisted of five Divisions: Gene Research, Developmental Biology and Medicine, Organ Pathophysiology, Cancer Control and Brain Sciences, including sixteen departments with full research facilities.


In 1997, the Cancer Cell Repository was converted to a Cell Resource Center for Biomedical Research, and the Genome Research Center was founded in 2004. Five years later, the Ministry of Education, Culture, Sports and Science officially recognized IDAC as a Research Center for Aging and Cancer in 2009. In December 2018, the Department of Cognitive Health Science was established; and in addition, the Department of Metabolic Bioregulation in January 2019. The Institute is often abbreviated and called “Kareiken” in Japanese.


Successive directors and hospital directors

Research Institute of Tuberculosis and Leprosy

Directors (since establishment in 1941)

  • Taizo Kumagai (1941-1948)
  • Toshiaki Ebina (1948-1963)
  • Saburo Sato (1963-1968)
  • Chikashi Suzuki (1968-1974)
  • Tatsuo Saito (1974-1978)
  • Haruo Sato (1978-1984)
  • Kiyoshi Konno (1984-1987)
  • Shigeru Tsuiki (1987-1990)
  • Akira Wakui (1990-1991)
  • Masakichi Motomiya (1991-1992)
  • Tamio Watanabe (1992-1993)

Institute of Development, Aging and Cancer


  • Tamio Watanabe (1993-1996)
  • Tasuke Konno (1996-1998)
  • Shigefumi Fujimura (1998-2000)
  • Masuo Obinata (2000-2006)
  • Hiroshi Fukuda (2006-2012)
  • Masanobu Satake (2012-2014)
  • Ryuta Kawashima (2014-present)

Research Institute of Tuberculosis and Leprosy

Hospital directors (since establishment in 1964)

  • Sutemi Oka (1964-1973)
  • Tatsuo Saito (1973 -1974)
  • Kiyoshi Konno (1974-1982)
  • Akira Wakui (1982-1984)
  • Tasuku Nakata (1984-1989)
  • Akira Wakui (1989-1990)
  • Masayoshi Motomiya (1990-1991)
  • Shigefumi Fujimura (1991-1993)

Institute of Development, Aging and Cancer

Hospital directors

  • Shigefumi Fujimura (1991-1993)
  • Ryunosuke Kanemaru (1998-2000)
Research Facilities

IDAC's world renowned research facilities are spread across three buildings and divided into seven divisions. Within these division are a total of twenty-two laboratories collaborating with one another to achieve "smart-aging". In addition, IDAC has three special facilities within the institute: the Cell Resource Center for Biomedical Research, the Smart Aging Research Center (S.A.R.C.) and the Pre-Clinical Research Center.

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Division of Aging Science

Dept. Gene Expression Regulation Hozumi MOTOHASHI
Dept. Experimental Immunology Toshiyuki TAKAI
Dept. Immunobiology Koetsu OGASAWARA
Dept. Molecular and Cellular Biology Hisanori HORIUCHI
Dept. Metabolic Bioregulation
Dept. Modomics Biology and Medicine Fan-Yan WEI
Dept. Project Programs Ryuta KAWASHIMA
Dept. In Silico Kengo KINOSHITA

Division of Cancer Science

Dept. Vascular Biology Yasufumi SATO
Dept. Molecular Oncology Kozo TANAKA
Dept. Cancer Biology Natsuko CHIBA
Dept. Clinical Oncology Chikashi ISHIOKA
Dept. Thoracic Surgery Yoshinori OKADA

Division of Brain Science

Dept. Developmental Neurobiology Toshihiko OGURA
Dept. Functional Brain Imaging Ryuta KAWASHIMA
Dept. Human Brain Science Motoaki SUGIURA
Dept. of Aging Research and Geriatric Medicine Yasuyuki TAKI
Dept. Cognitive Health Science Ryuta KAWASHIMA

Division of Cognitive Neuroscience

Div. Cognitive Neuroscience Ryuta KAWASHIMA
Department of New Therapeutics Innovation for Alzheimer’s and Dementia Yukitsuka KUDO
Department of New Therapeutics Innovation for Alzheimer’s and Dementia Hiroyuki ARAI

Cell Resource Center for Biological Research

The purpose of the Cell Resource Center for Biomedical Research is the collection, establishment, quality control, distribution of useful cell lines, and the construction of an extensive database for researchers worldwide.

Cell Resource Center for Biomedical Research Yasuhisa MATSUI

Pre-Clinical Research Center

The Pre-Clinical Research Center's main purpose is to determine the safety and effectiveness of devices, diagnostic products and treatment regimens that may be used for the prevention, treatment and diagnosis of diseases before any clinical trials begin.

Dept. Pre-Clinical Evaluation Tomoyuki YAMBE
Dept. Medical Engineering and Cardiology Tomoyuki YAMBE
Dept. Ubiquitous Sensing Ryuta KAWASHIMA
Dept. Biomedical Measurements Yoshifumi SAIJO
Dept. Respiratory Engineering Yoshinori OKADA

Center for Environmental Response Research

The Center for Environmental Response Research aims to clarify functional interactions between the aging process and stress response to environmental factors, such as environmental chemicals, pathogens and mechanical stimuli. The center's ultimate goal is to delay the aging process and alleviate age-related diseases by regulating defense mechanisms and increasing cytoprotection capacities.

Department of Redox Regulation Hozumi MOTOHASHI
Department of Metabolic Stress Regulation Fan-Yan WEI
Department of Chromosomal Stress Regulation Kozo TANAKA
Department of Bioinformatics
Common Facilities

IDAC features several common facilities located on the 1st floor of the Basic Aging Building to assist and provide its members the opportunity to advance their research. In addition, dedicated staff provide support to not only IDAC members, but visitors coming to the institute as well.

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Common Facilities

Laboratory Animal Resources Toshiyuki TAKAI
Center of Research Instruments Fan-Yan WEI
The Global Affairs and Public Relations Office Ryuta KAWASHIMA
Administration Office Administration Office


IDAC Fellow

IDAC Fellow Akira YASUI
IDAC Fellow Yukitsuka KUDO



Brain Imaging

IDAC is one of the most distinguished research institutes in the world for brain imaging with its advanced imaging facilities and large scale brain image databases that brings IDAC to the forefront of brain research.

Cell Center

The Cell Resource Center for Biomedical Research was established to collect, control, and distribute various human and animal cancer cells, while providing an extensive database for researchers worldwide. Cell lines include transplantable animal cell lines, such as the Yoshida sarcoma and rat ascites hepatoma (AH series), as well as human cell lines such as the murine and hybridoma cells.

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The Center of Research Instruments was established in April 2003 to manage IDAC's laboratory equipment for medical and biological research. The following is a list of available instruments for all IDAC members to utilize.

Equipment Function Manufacturer
LAS4000mini Quantitative Imaging of Gels & Blots by Chemiluminescence GE Healthcare
FLA-7000 Laser Scanner. Fluorescence, IP, and Digitization GE Healthcare
ABI PRISM 310 Genetic Analyzer Applied Biosystems
ABI 3130 Genetic Analyzer,4-capillary Applied Biosystems
ABI 3130xl Genetic Analyzer,16-capillary Applied Biosystems
LSM5 PASCAL Confocal Laser Scanning Microscope Carl Zeiss
BIACORE2000 Bio-Molecular Interaction Analysis GE Healthcare
DU 640 UV/VIS Spectrophotometer BECKMAN
SpectraMax M2e Microplate Reader Molecular Devices
Lmax II 384 Luminometer Molecular Devices
OPT Scanner 3001 Optical Projection Tomography Medical Research Council Technology
BR-3000L Bioshaker TAITEC
Cytomics FC500 Flow Cytometry Systems, 5-color Analysis BECKMAN COULTER
EPICS ALTRA Flow Cytometry Systems, Hyper Sort Cell Sorting System BECKMAN COULTER
MC10000 Wide Format Printer EPSON
iPF8300 Large-Format Inkjet Printer CANON
AVIZO High Performance 3D Visualization Software VSG
CS150GX Micro Ultra Centrifuge  Hitachi Koki
CM1900 Disinfecting Cryostats for Sectioning LEICA
BZ-9000 Fluorescence Microscopy KEYENCE
HA-320RS Laminator(Pouch) MEIKO SHOKAI
CP65 β Ultracentrifuge Hitachi Koki Co., Ltd.
4D-Nucleofector Transfection Lonza
IVIS Lumina II Quantitative Fluorescent and Bioluminescent Imaging in Vivo SPI (Caliper Life Sciences)
FV1000MPE Multiphoton Laser Scanning Microscope OLYMPUS




Admission & Courses


IDAC is always on the look-out for talented individuals who excel in their area of ​​study and are able to find practical applications for their research. If you would like to join us for your future endeavors, please choose your area of interest to find out more about what we do and what we have to offer.


Mechanisms of Aging


Overcoming Intractable Cancers


Overcoming Age-Related Brain Diseases


Achieving "Smart Aging"

Maps & Directions

Institute of Development, Aging and Cancer, Tohoku University 4-1 Seiryocho, Aobaku, Sendai 980-8575, Japan


Institute Map

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Seiryo Campus Map

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Access from Sendai Station

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Proceed to the subway entrance at the lower ground level of Sendai Station. Get on the train bound for Izumi-Chuo Station. In around 4 minutes, you will arrive Kita-Yobancho Subway Station. IDAC is around 15 minutes on foot after exiting the Kita-Yobancho Subway Station. Subway trains usually operate in 3 to 13 minute intervals.



Proceed to the bus terminal right outside of Sendai Station and head toward bus stop #25. Board the Sendai city bus #899 to Shiheimachi/Kitayama-Jyunkan. Stay on the bus for around 20 minutes, then disembark at the stop labeled "Daigaku-Byoin-Mae". This bus stop is directly in front of the Tohoku University Hospital. Head north for around 5 minutes to reach IDAC. The city buses run in 20 minute intervals.



From Sendai Station, IDAC is around 10 - 15 minutes by taxi service, and will cost around 1,500 - 2,000 yen.


Access from Sendai International Airport (SDJ)

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Sendai Airport to Sendai Station via Sendai Airport Access Line will take around 30 minutes and costs 650 yen.

Give to IDAC

Join us to drive the development of new knowledge and to develop evidence-based solutions for improving the lives of millions.


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The Institute of Development, Aging and Cancer (IDAC) will always be a place where the best young minds can come to find their life’s work. Help us provide more scholarships and fellowships, and at the same time bring new richness to the student experience: more opportunities to interact with professors, to engage in independent research, to participate in internships, community-focused programs, and to make new innovative discoveries.


We gratefully welcome donations for the purpose of improving and developing academic research and education at IDAC. For online donations, please click on the "Give to IDAC" button below (secure external site) and kindly mention IDAC as the beneficiary. For direct deposit donations, please contact IDAC's Office of Accounting via e-mail and/or phone.


Thank you in advance for your kind consideration and your donation.


Office of Accounting, IDAC

Phone: +(81) 227-178-447


Contact Us

Institute of Development, Aging and Cancer, Tohoku University

4-1 Seiryocho, Aobaku, Sendai 980-8575, Japan Phone: +(81) 22-717-8496 E-mail: ida-pr-office* (Please convert "*" into "@".)
Overcoming Intractable Cancers

Research focusing on overcoming intractable cancers consists of the following departments.

Overcoming Age-Related Brain Diseases

Research focusing on overcoming intractable cancers consists of the following departments.

Achieving "Smart Aging"

Research focusing on achieving "smart aging" consists of the following departments.


Contact Us

Institute of Development, Aging and Cancer, Tohoku University 4-1 Seiryocho, Aobaku, Sendai 980-8575, Japan

Phone: +(81) 22-717-8496

IDAC's Global Affiliations

Hokkaido Regional Affiliates

  • Department of Gastroenterology, School of Medicine - Sapporo Medical University
  • Department of Tissue Cytology, Graduate School of Medicine - Hokkaido University
  • Department of Fisheries Food Science, Faculty of Marine Science and Technology - Tokai University
  • Advanced Medical Engineering Research Center - Asahikawa Medical University

Tohoku Regional Affiliates

  • Faculty of Liberal Arts - Tohoku Gakuin University
  • Graduate School of Medicine, Faculty of Medicine - Yamagata University
  • Frontier Research Institute for Interdisciplinary Sciences - Tohoku University
  • Fukushima Medical University
  • Graduate School of Agricultural Science/Faculty of Agriculture - Tohoku University
  • Graduate School of Dentistry - Tohoku University
  • Graduate School of Pharmaceutical Sciences - Tohoku University
  • Graduate School of International Cultural Studies - Tohoku University
  • Graduate School of Life Sciences - Tohoku University
  • Graduate School of Medicine/Faculty of Medicine - Akita University
  • Food Industry Group - Miyagi University
  • Miyagi Cancer Center
  • Department of Functional Morphology, Faculty of Pharmaceutical Sciences - Ohu University
  • Department of Pharmacology and the Department of Oral Pathology Analysis and Control, Faculty of Dentistry - Ohu University
  • Yamagata Prefectural Central Hospital
  • Graduate School of Engineering - Tohoku University
  • School of Medicine - Tohoku Medical and Pharmaceutical University
  • Tohoku Institute of Technology
  • Tohoku University Hospital
  • Smart-Aging Research Center (S.A.R.C.)
  • Kanto Regional Affiliates

    • Natural Sciences Research Institute - Ochanomizu University
    • Graduate School of Science and Engineering - Hirosaki University
    • Institute of Medical Science - University of Tokyo
    • Graduate School of Agriculture and Life Sciences - The University of Tokyo
    • National Institute of Advanced Industrial Science and Technology (AIST)
    • Medical Genetics - University of Tsukuba
    • Faculty of Applied Biology - Tokyo University of Technology
    • Division of Medical Devices - National Institute of Health Sciences
    • Faculty of Science - Japan Women's University
    • Graduate School of Medical and Dental Sciences - Tokyo Medical and Dental University
    • Graduate School of Comprehensive Research - Yamanashi University
    • Department of Rehabilitation - Teikyo University Chiba Medical Center
    • Graduate School of Health Sciences - Gunma University
    • Genome Biology Research Field - National Cancer Center Research Institute
    • Marmoset Medical and Biological Laboratories - Central Institute for Experimental Animals
    • Faculty of Engineering - Tokyo Institute of Technology
    • Graduate School of Medicine - The University of Tokyo
    • Graduate School of Engineering - The University of Tokyo
    • Institute of Mental Health - National Center of Neurology and Psychiatry
    • National Institutes for Quantum and Radiological Science and Technology

    Chubu Regional Affiliates

    • Aichi Medical University
    • Faculty of Science - Shizuoka University
    • Graduate School of Pharmaceutical Sciences - Nagoya City University
    • Center for Liberal Arts - Tokai University
    • Respiratory Surgery, School of Medicine - Fujita Medical University

    Kansai Regional Affiliates

    • Biosignal Research Center - Kobe University
    • Institute of Advanced Co-creation - Osaka University
    • Faculty of Agriculture - Kindai University
    • Graduate School of Frontier Biosciences - Osaka University
    • Graduate School of Biostudies - Kyoto University
    • Department of Environmental Engineering - Osaka Institute of Technology
    • Department of Gastroenterology - Kyoto Prefectural University of Medicine
    • Cell Function Control, Graduate School of Medicine - Osaka City University
    • Clinical Laboratory, Department of Cardiovascular Medicine - Kyoto University

    Chugoku Regional Affiliates

    • Department of Cell Physiology, Graduate School of Biomedical Sciences - Okayama University
    • Pharmacology, Graduate School of Medicine - Yamaguchi University

    Shikoku Regional Affiliates

    • Artificial Organ Research Group, Health and Medical Engineering Research Division - National Institute of Advanced Industrial Science and Technology

    Kyushu Regional Affiliates

    • Biomolecule Analysis Support Division, School of Medicine Joint Usage Research Center - Nagasaki University
    • Institute of Core Education - Kyushu University
    • Molecular Physiology Course, Graduate School of Life Sciences (Medical) - Kumamoto University
    • International Research Center for Medical Sciences (IRCMS), Kumamoto University
    • Department of Pathology, School of Medicine - Miyazaki University
    • Graduate School of Thoracic Disease Research - Kyushu University
    • Functional Biochemistry Course, Infectious Biology - Fukuoka Dental College