◇ 2025年10月6日（月）加齢研セミナーのご案内
| 日時： | 2025年10月6日（月）16時～ |
| 場所： | 加齢医学研究所 実験研究棟7階 セミナー室1 |
| 演題： | Circadian Clock Regulation of Longevity |
| 講師： | Joseph Takahashi, Ph.D. |
| 所属： | Department of Neuroscience, University of Texas Southwestern Medical Center |
| 要旨： | We live on a planet with a 24-hour day-night cycle that determines the energetic cycle of essentially all forms of life. To anticipate these daily cycles in the environment, living systems have evolved circadian clocks to predict the 24-hour passage of time. My laboratory discovered the first gene that controls circadian rhythms in mouse and humans, known as the “Clock” gene. This gene acts as the primary regulator of circadian behavior and physiology in mammals. In addition, the circadian clock gene network interacts directly with many other pathways in the cell. These include metabolism, immune function, cardiovascular function, cell growth, as well as, the majority of the “hallmark of aging” pathways. With respect to metabolism, the timing of nutrient consumption is critical, and we have found that time restriction and circadian alignment of feeding are critical factors for extension of lifespan under caloric restriction. Because the circadian gene network is a conserved regulator of aging and longevity in mice and humans and because circadian transcriptional drive declines with age, we are testing interventions that rescue circadian amplitude as agents to promote healthspan and lifespan. We propose that the circadian gene network is a novel target for aging and longevity. |
| 担当・連絡先： | 佐藤 亜希子（統合生理学研究分野・内線8544） |