Secretariat, Alumni Association, IDAC
Date	Friday, 10 October 2025, 13:00～
Room	7th Floor, Seminar Room 1, IDAC Center for Basic Aging Research
Title	The Precision of Mistakes: Dynamic mRNA Translation Fidelity in Development and Disease
Speaker	Dr. Kotaro Fujii
Affiliation	The Department of Molecular Genetics & Microbiology, University of Florida Center for NeuroGenetics
Organizer	Kawaoka Shinpei (Dept. Integrative Bioanalytics, ext.8568)
Abstract	A key question in gene regulation is how information encoded in the genome is expressed with high fidelity and precision to enable cells to adapt to their environment. By developing the first transgenic mouse model monitoring mRNA translation errors in vivo, we delineated the first spatiotemporal landscape of mRNA translation fidelity, indicating brain and muscle tissues with the highest fidelity, which was gradually established across embryonic development. Using brain organoids, we further revealed a significant impact of increasing translation errors on neuron differentiation. We also discovered the regulatory principle of translation fidelity for each transcript through codon optimality. Given the impact of translation errors for protein homeostasis and immune activation through error-containing peptide presentation, we will further discuss the hidden roles of translation fidelity for human health.