| Secretariat, Alumni Association, IDAC | |
| Date | Monday, 29 September 2025, 16:00～ |
|---|---|
| Room | 7th Floor, Seminar Room 1, IDAC Center for Basic Aging Research |
| Title | Regulation of Aging and Longevity by Ppp1r17-Expressing Neurons in the Hypothalamus |
| Speaker | Kyohei Tokizane, PhD |
| Affiliation | Department of Developmental Biology, Washington University in St. Louis School of Medicine |
| Organizer | Akiko Satoh (Department of Integrative Physiology, ext.8544) |
| Abstract | Aging is characterized by a progressive decline in various physiological functions, and increasing evidence suggests that inter-organ communication plays a critical role in this process. In mammals, the hypothalamus serves as a key regulator of inter-organ interactions, as well as aging and longevity. Among hypothalamic regions, a specific population of Ppp1r17-expressing neurons in the dorsomedial hypothalamus (DMH) regulates white adipose tissue function through the sympathetic nervous system, thereby affecting aging and lifespan. Specifically, age-related changes in the subcellular localization of Ppp1r17, regulated by protein kinase G (PKG; Prkg1), disrupt synaptic function in these DMH neurons during aging, leading to white adipose tissue dysfunction. |
This seminar has been postponed. We will announce the new date as soon as it is determined. (Added September 22)