Secretariat, Alumni Association, IDAC
Date Monday, 3 June 2024, 16:00~
Room 7th floor, Seminar Room 1, IDAC Center for Basic Aging Research
Title Molecular function/regulation of Chromosomal SUMOylation in mitosis for accurate genome transmission.
Speaker Yoshiaki Azuma
Affiliation Department of Molecular Biosciences, University of Kansas
Organizer Kozo Tanaka (Department of Molecular Oncology, ext 8491)
Abstract Chromosome segregation during mitosis is a fundamental process in which the replicated genome is evenly inherited by two daughter cells. Post-translational modification by SUMO (SUMOylation) has shown to be essential for this genome transmission process in eukaryotes as such either inhibition of SUMOylation or deSUMOylation in mitosis causes mis-segregation of chromosomes. Many chromosomal proteins were identified as mitotic chromosomal SUMOylated proteins, including DNA Topoisomerase IIα (TopoIIα) and several CENPs. Currently, assembly of protein complex composed with SUMOylated protein and SUMO-interacting motif (SIM) containing proteins is proposed to be a major role of SUMOylation, the molecular function of the SUMOylation of each target proteins are still under investigation. This presentation, I will discuss our finding for molecular functions of mitotic SUMOylation on chromosome segregation by focusing its role on regulation of mitotic checkpoint activities and potential novel regulation by SUMO-targeting remodeling enzyme.