Secretariat, Alumni Association, IDAC
Date Monday, 11 December 2023, 15:30~
Room 7th Floor, Seminar Room 1,IDAC Center for Basic Aging Research
Title NAD World 3.0
The importance of inter-tissue communications in mammalian aging and longevity control and anti-aging intervention.
Speaker Shin-ichiro Imai, MD, PhD
Theodore and Bertha Bryan Distinguished Professor
Affiliation Department of Developmental Biology, Department of Medicine (Joint), Washington University School of Medicine
Organizer Akiko Satoh (Department of Integrative Physiology, ext. 8544)
Abstract Our major objective is to understand a systemic regulatory network for mammalian aging and longevity control and translate the knowledge to an effective anti-aging intervention for humans. Recently, we have identified a specific neural population in the dorsomedial hypothalamus (DMH) that counteracts aging and promotes longevity through the control of a feedback loop between the hypothalamus and white adipose tissue (WAT). These neurons send a signal to WAT through the sympathetic nervous system, stimulating the secretion of extracellular vesicles (EVs) that contain extracellular nicotinamide phosphoribosyltransferase (eNAMPT-EVs). eNAMPT-EVs then increases hypothalamic NAD+ levels, particularly in the DMH. We have demonstrated that stimulating this feedback loop can delay aging and extend lifespan in mice. On the other hand, nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been proven to show significant anti-aging effects in mice and also has been reported to show significant beneficial effects in several human clinical trials. In this seminar, I will discuss the importance of inter-tissue communications for mammalian aging and longevity control and anti-aging intervention to aim to accomplish “Productive Aging” in our society.