| Date |
Thursday, 26 January 2023, 13:30～15:00 |
| Room |
Web |
| Title |
Zinc homeostasis and proteostasis in cells |
| Speaker |
Kenji Inaba Ph.D |
| Affiliation |
Institute of Multidisciplinary Research for Advanced Materials |
| Organizer |
Hitoshi Yamagata, Dept. of Aging Research and Geriatric Medicine・ext 8559 |
| Abstract |
In recent years, we have been working on cellular protein quality control systems governed by chemical parameters such as redox, pH and metal ions, and discovered that zinc ions play a particular role for proteostasis at the ER-Golgi interface. To understand molecular mechanisms of the zinc-dependent protein quality control, we have developed a method for quantitative zinc imaging in each intracellular organelle and determined a high-resolution cryo-EM structure of one of the zinc transporters that control zinc concentration in the Golgi apparatus. In this lecture, I plan to present our recent findings of the close correlation between zinc homeostasis and proteostasis, and also introduce some diseases caused by the disruption of intracellular zinc homeostasis. |
