||Friday, 10 March 2023, 16:00〜
||International Conference Room, Center for Smart-Aging Research, 1F, (IDAC)
||Immunoregulatory receptors and drug discovery – What is my true heart of research?
||Professor Toshiyuki Takai
||Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University
||Mei-Tzu Su, Dept. Experimental Immunology ext 8504
||During my years as a graduate student at Kyoto University, I was sticking to jobs for cDNA cloning of neuronal ion channel molecules. After a few career changes, I have been working at IDAC on the immunologic research for about 25 years, which is originated from my jobs as a visiting investigator during 1992–1993 at Sloan-Kettering Institute, USA. My research interest has been the elucidating the mechanism of immune regulation by activating and inhibitory immunoreceptors and its application to drug discovery. As you know well, the basis of the concept for cancer immunotherapy by inhibiting immune checkpoint is derived from achievements by many researchers dedicated to immunoregulatory receptors. Our lab is now considering that the utilization of immune checkpoint, namely inhibitory immunoreceptors, could be applicable also to the drug discovery toward autoimmune disease and neurodegenerative disease. Researchers will often be struggled due to various against situations and problems. In my talk today, I will grossly overview the 25-years investigations in our lab, and I want to think about what the true heart of researchers is, as words of cheers for young investigators of IDAC.