Professor Yoshinori OKADA

The Department of Respiratory Engineering was first established in the Pre-Clinical Research Center of IDAC in April 2015 as one of the 4 departments of the Institute. The purpose of this department is to improve the quality of life and the survivability of patients with respiratory failure by promoting lung transplantation, developing new devices utilized in lung transplant surgery, and creating new devices and therapeutic modality. The three research areas of this department are: the Development of new devices for prolonged lung preservation, the Development of new cardiopulmonary support systems without anti-coagulation therapy, and finally, the Elucidating mechanisms of dyspnea.

Research Topics:
• Development of devices to promote long term lung preservation
• Development of anti-clotting drugs and heart-lung assist devices.
• The use of physiological mechanisms to elucidate breathing difficulties.
Jan. 2023 ~ Dec. 2023
1. Inoue C, Ohkouchi S, Chonan T, Amata A, Hirama T, Saito-Koyama R, Kawabata Y, Suzuki T, Okada Y, Tanaka A, Kurosawa H. A case report of Indium lung with progressive emphysema and fibrosis underwent lung unilateral transplantation 20 years after the end of the exposure. Diagn Pathol. England; 2023 Jan;18(1):10. doi:10.1186/s13000-023-01303-1 PMCID: PMC9883848

2. Takahashi R, Takahashi T, Okada Y, Kohzuki M, Ebihara S. Factors associated with quality of life in patients receiving lung transplantation: a cross-sectional study. BMC Pulm Med. England; 2023 Jun;23(1):225. doi:10.1186/s12890-023-02526-0 PMCID: PMC10288771

3. Watanabe T, Matsuo S, Watanabe Y, Hirama T, Matsuda Y, Noda M, Niikawa H, Oishi H, Suzuki Y, Ejima Y, Toyama H, Saiki Y, Okada Y. Bilateral lung transplant with pulmonary artery reconstruction using donor aorta for pulmonary hypertension with a giant pulmonary arterial aneurysm. Eur J Cardiothorac Surg. Germany; 2023 Jun;63(6):ezad234. doi:10.1093/ejcts/ezad234 PMID: 37335855

4. Ikeda M, Wakatsuki Y, Oga T, Tokuno J, Sugimoto S, Ishihara M, Okada Y, Akiba M, Kayawake H, Tanaka S, Yamada Y, Yutaka Y, Ohsumi A, Nakajima D, Hamaji M, Kimura J, Chen-Yoshikawa TF, Date H. One-year change in the health status predicts the subsequent hospitalization and mortality in patients waitlisted for lung transplantation in Japan. Respir Investig. Netherlands; 2023 Jul;61(4):478–484. doi:10.1016/j.resinv.2023.04.004 PMID: 37196571

5. Ui M, Hirama T, Akiba M, Honda M, Kikuchi T, Okada Y. Cellular and humoral immune responses after a third dose of SARS-CoV-2 mRNA vaccine in lung transplant recipients in Japan. Vaccine. Netherlands; 2023 Jul;41(31):4534–4540. doi:10.1016/j.vaccine.2023.06.011 PMCID: PMC10250153

6. Fukutomi T, Taniyama Y, Sato C, Okamoto H, Niikawa H, Okada Y, Kamei T. A Case of Esophageal Cancer Treated by Thoracoscopic Esophagectomy after Bilateral Cadaveric Lung Transplantation. Ann Thorac Cardiovasc Surg. Japan; 2023 Aug;29(4):200–205. doi:10.5761/ PMCID: PMC10466120

7. Oishi H, Okada Y, Suzuki Y, Hirama T, Ejima Y, Fujimaki S-I, Sugawara S, Okubo N, Horiuchi H. Impact of intraoperative use of venovenous extracorporeal membrane oxygenation on the status of von Willebrand factor large multimers during single lung transplantation. J Thorac Dis. China; 2023 Aug;15(8):4262–4272. doi:10.21037/jtd-23-275 PMCID: PMC10482656

8. Hayasaka K, Ohkouchi S, Saito-Koyama R, Suzuki Y, Okazaki K, Sekine H, Watanabe T, Motohashi H, Okada Y. Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response. Am J Transplant. United States; 2023 Sep;S1600-6135(23)00692–5. doi:10.1016/j.ajt.2023.09.004 PMID: 37734444

9. Hirama T, Okada Y. Roles of respirologists in lung transplantation in Japan: narrative review. J Thorac Dis. China; 2023 Sep;15(9):5174–5181. doi:10.21037/jtd-22-1716 PMCID: PMC10586989

10. Oishi H, Okada Y, Sato M, Nakajima J, Nakajima D, Shiraishi T, Sato T, Kanou T, Shintani Y, Miyoshi K, Toyooka S, Maeda S, Chida M, Matsumoto K, Nagayasu T, Suzuki H, Yoshino I, Matsuda Y, Hoshikawa Y, Date H. Prognostic factors for lung transplant recipients focusing on age and gender: the Japanese lung transplantation report 2022. Surg Today. Japan; 2023 Oct;53(10):1188–1198. doi:10.1007/s00595-023-02686-w PMCID: PMC10520150

11. Watanabe Y, Murai S, Ueda K, Watanabe T, Hirama T, Oishi H, Noda M, Okada Y. A straightforward guide to the swine left upper lobar transplant model: procedures and techniques. Multimed Man Cardiothorac Surg. 2023 Nov;2023. doi:10.1510/mmcts.2023.075 PMID: 37947495

12. Oishi H, Hirama T, Watanabe T, Watanabe Y, Niikawa H, Noda M, Suzuki T, Notsuda H, Okada Y. Single lung transplantation using a lung graft from a donor whose contralateral lung is not suitable for lung transplantation. Gen Thorac Cardiovasc Surg. Japan; 2024 Jan; doi:10.1007/s11748-023-01999-4 PMID: 38180695