Secretariat, Alumni Association, IDAC
Date Monday, September 4, 2017 (17:00 – onward)
Room Medium-size Conference Room, IDAC Center for Clinical Aging Research 1F
Title T cell repertoire selection in the thymus
Speaker Takeshi Nitta
Affiliation Dept. of Immunology, Graduate School of Medicine, The University of Tokyo
Organizer Koetsu Ogasawara (Department of Immunobiology ext.8579)
Abstract The thymus is an organ for T cell repertoire selection. Cortical thymic epithelial cells possess unique protein degradation machinery such as thymoproteasome, which produces a unique set of MHC-bound self-peptides and thereby control positive selection of T cells. Here we found that human PSMB11 gene, which encodes a thymmoproteasome subunit, has many ‘loss-of-function’ variations at high frequency. These PSMB11 variations alter the CD8 T cell selection in mice, and one of them is associated with a risk of an autoimmune disease in human. Our findings suggest that, in addition to the MHC haplotype, antigen peptide-processing variation exerts a significant influence on T cell repertoire selection and disease susceptibility.