| Date |
Tuesday, June 13, 2017 (13:00 to 14:30) |
| Room |
7th Floor, Seminar Room 1, IDAC Center for Basic Aging Research |
| Title |
Light and Dark Sides of Polarity Proteins in Blood Vessel |
| Speaker |
Dr. Masanori Nakayama |
| Affiliation |
Max-Planck-Institute for Heart and Lung Research, Laboratory for Cell Polarity and Organogenesis |
| Organizer |
Miho Kobayashi (Department of Vascular Biology・ext 8532) |
| Abstract |
Polarity is a fundamental feature of all types of cells in tissues. Loss of polarity is a hallmark of diseases such as cancer and atherosclerosis. The PAR protein complex, composed of PAR-3 and atypical PKC (aPKC), plays a significant role in many polarization events. Although I have shown that PAR-3 and aPKC control VEGF signaling pathway during angiogenic vessel growth (Nature 2010 and Nat Cell Biol 2013), the role of these proteins in endothelial polarity in vivo remains elusive. Since 2013, I have established a laboratory in Max Planck Institute in Bad Nauheim and we have addressed this issue. Here, we show that aPKC (but not PAR-3) is the key factor of poor prognosis of vascular malignant tumor, angiosarcoma. On the other hand, PAR-3 indirectly controls endothelial planar cell polarity and vascular inflammatory responses. Our findings highlight importance of cell polarity factors in endothelial health and disease. |
