| Date |
Friday, November 4th, 2016 (17:00 – onward) |
| Room |
7th Floor, Seminar Room 1, IDAC Center for Basic Aging Research |
| Title |
Chromosomal instability by the destabilization of the ICS network |
| Speaker |
Yuji Tanno, Ph.D. |
| Affiliation |
Laboratory of Chromosome Dynamics, IMCB, The University of Tokyo |
| Organizer |
Kenji Iemura (Department of Molecular Oncology・ext.8490) |
| Abstract |
The inner centromere-shugoshin network (ICS network) establishes functional inner centromere in mitosis, which plays a crucial role in faithful chromosome segregation through maintaining sister chromatid cohesion and promoting bi-orientation of kinetochore-microtubule attachment. Chromosomal instability (CIN) is a major trait of cancer cells and it is a potent driver of tumor progression. Recently, we reported that a number of the CIN+ human cell lines exhibit the destabilization of the ICS network (Y. Tanno et al. 2015, Science). In this seminar, we would like to discuss the mechanism of the establishment of inner centromere and the molecular basis of its destabilization. |
