Secretariat, Alumni Association, IDAC
Date Friday, August 26th, 2016 (17:00 – onward)
Room 7th Floor, Seminar Room 1, IDAC Center for Basic Aging Research
Title The Proteasome: Destruction for Life
Speaker Shigeo MURATA
Affiliation Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Organizer Hiroki SEKINE, Dept. of Gene Expression Regulation (ext: 8553)
Abstract The proteasome is an essential intracellular proteolytic enzyme complex that degrades ubiquitinated proteins in eukaryotes. Increase or decrease in the proteasome activity has been shown to be associated with the pathogenesis of human diseases such as malignancies, inflammation, neurodegeneration and aging. Thus, understanding the mechanisms that regulate the proteasome in mammals is of great importance. In this seminar, I will present our most recent findings regarding qualitative and quantitative regulation of the proteasome and their biological consequence.