東北大学加齢医学研究所 加齢医学研究拠点 | Institute of Development, Aging and Cancer, Tohoku University

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◇平成27年3月19日(木)加齢研セミナ-のご案内
日時: 平成27年3月19日(木)午後6時30分〜
場所: 加齢研スマートエイジング棟1階国際会議室
演題: 頸動脈小体内の神経幹細胞 低酸素順応における役割
講師: ホセ・ロペ・バルネオ
所属: セビリア大学生物医学研究所
担当: 近藤 丘 (呼吸器外科学分野・内線8521)
連絡先:星川 康(内線8521 )
要旨: Peripheral chemoreceptors (e.g. carotid body (CB)) contain specialized O2-sensitive cells with K+ channels which are inhibited during hypoxia. These cells release transmitters that activate sensory fibers (“chemo-sensory synapses”) conveying the information to the respiratory center thus triggering homeostatic cardiorespiratory reflexes (e.g. hyperventilation and sympathetic activation). During protracted hypoxia the CB grows several folds its normal size thus increasing the excitatory input to the respiratory center. This adaptive response is necessary for acclimatization to hypoxemia, a condition affecting to high altitude sojourners or patients with obstructive lung diseases. CB growth is due to activation of a resident population of adult CB stem cells, which form ”chemo-proliferative” synapses with the O2-sensitive glomus cells. Upon exposure to hypoxia, transmitters released from glomus cells (e.g. endothelin 1) induce stem cell-dependent growth of the CB parenchyma. These findings reveal the mechanisms underlying thus far unexplained fundamental biomedical processes. They may also help expansion of CB tissue in vitro and facilitate its use in cell therapy for Parkinson’s disease.

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