東北大学加齢医学研究所 加齢医学研究拠点 | Institute of Development, Aging and Cancer, Tohoku University

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◇平成26年7月23日(水)加齢研セミナ-のご案内
日時: 平成26年7月23日(水)午後5時30分~
場所: 加齢研実験研究棟7階 セミナー室1
演題: dentification of an inhibitor of AXL kinase to induce epithelial differentiation of human lung tissue-derived progenitor cells.
講師: 藤野 直也 先生
所属: 東北大学大学院医学系研究科 先進感染症予防学
担当: 高井 俊行 (遺伝子導入研究分野 ・内線 8501 )
要旨: Differentiation of tissue-specific stem/progenitor cells has a role in homeostasis and repair. We previously isolated progenitor cells from adult human lung tissues, which had the ability to generate alveolar epithelial type II (ATII) cells (Fujino N, et al. Lab Invest 2011;91:363). However molecular mechanisms underlying the progenitor cell differentiation remain poorly understood. To address this question, we carried out a phenotypic screen using a small molecule library consisting of stem cell modulators and a diverse set of kinase inhibitors. We identified an inhibitor of AXL receptor tyrosine kinase, which drove the lung progenitor cells towards ATII cells via mesenchymal-to-epithelial transition. Our study reveals that AXL kinase acts as a barrier in the epithelial differentiation of human lung progenitor cells.

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