東北大学加齢医学研究所 加齢医学研究拠点 | Institute of Development, Aging and Cancer, Tohoku University

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◇平成26年3月26日(水)加齢研セミナ-のご案内
日時: 平成26年3月26日(水)17時30分~
場所: 加齢研実験研究棟7階 セミナー室1
演題: GATA因子による造血幹細胞とT細胞の発生の制御
講師: Prof. James Douglas Engel
所属: University of Michigan
担当: 本橋 ほづみ(所属 遺伝子発現制御分野 ・内線8550)
要旨: GATA transcription factors are known to be critical regulators of many aspects of hematopoiesis, and yet we continue to unveil new functions for these important regulatory proteins even more than two decades after their original discovery. GATA2 and GATA3 have both recently been shown to contribute to HSC homeostasis, and the molecular mechanisms that specify the two very different activities that are executed by the two proteins are yielding to continued molecular genetic analysis. Further, GATA3 has been known for more than a decade to be essential for several aspects of T cell development, and recent studies from our lab have demonstrated that GATA3 is a master regulator of T lymphopoiesis; i.e. no T cells are generated in its absence. Very recent analysis of the molecular mechanisms executed by GATA3 in T cells have revealed startling new observations, perhaps providing initial glimpses into how one of the oldest problems in immunology, allelic exclusion, is achieved.

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