東北大学加齢医学研究所 加齢医学研究拠点 | Institute of Development, Aging and Cancer, Tohoku University

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◇平成24年6月13日(水)加齢研セミナ-(NM-GCOEセミナーとの共催)のご案内
日時: 平成24年6月13日(水)16時~17時30分
場所: 加齢研セミナー室1, 2
演題: Neural Control of Vascular Development In the Skin
講師: 向山 洋介
所属: Principal Investigator,National Heart Lung and Blood Institute,NIH,Bethesda,USA
担当: 佐藤靖史 (所属 腫瘍循環研究分野  内線:8532 )
要旨: Angiogenesis is a potential therapeutic target in cancer and many other diseases. But what controls the formation of hierarchical and elaborated vascular network during angiogenesis remains elusive. To study the intricate processes of vascular branching, we have developed a beautiful and powerful embryonic skin vasculature model, which exhibits a directly observable vascular network with an anatomically recognizable pattern. In the limb skin, the arterial branching pattern coincides with the branching pattern of pre-established sensory nerves during angiogenesis. Our studies establish two distinct mechanisms underlie the anatomical proximity and adjacent patterning of sensory nerves and arteries: nerve-derived VEGF-A controls arterial differentiation, and nerve-derived chemokine ligand CXCL12 controls vessel branching and alignment with nerves. Recently, we have also found that in the limb skin, nerves modulate TGF?s, which influence lymphatic vessel development. Further genetic studies demonstratethat TGF? signaling functions as a negative regulator for the formation oflymphatic vessel network. These studies suggest a new concept in angiogenesis and lymphangiogenesis: namely that the coordinated local action of patterning and differentiation mechanisms mediated by tissue sub-structures, such as sensory nerves in the skin, underlies organ specific vascular network.

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