東北大学加齢医学研究所 加齢医学研究拠点 | Institute of Development, Aging and Cancer, Tohoku University

研究活動

プロジェクト研究推進分野(東海林グループ)

教授(兼) 医博 川島 隆太
准教授 医博 東海林 亙
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研究内容

臓器・組織に脳からの指令を伝える神経系と酸素や栄養を運ぶ血管系は目的は異なるものの、どちらも体のすみずみまでネットワークを張りめぐらせる器官である。以前までの研究では両者はそれぞれ異なるしくみで独立の制御をうけて形成されるという考えが主流であったが、私たちはゼブラフィッシュ胚を用いた研究から、神経軸索の伸長方向を定めることによってネットワーク形成の制御を行う分子群が、同様のメカニズムで血管系の発生制御をも行うことを報告してきた。現在さらに、コレステロール合成経路の変異系統にみられる神経と血管の異常を解析し、両者の発生・発達におけける共通の分子機構の解明をめざしている。

 


論文

  1. Imai H, Oomiya Y, Kikkawa S, Shoji W, Hibi M, Terashima T, Katsuyama Y.,Dynamic changes in the gene expression of zebrafish Reelin receptorsduring embryogenesis and hatching period. Dev Growth Differ. 54,p253-263, 2012
  2. Tanaka, H., Nojima, Y., Shoji, W., Sato, M., Nakayama, R., Ohshima, T., Okamoto, H., Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons, Dev. Dyn., 240, p9-22, 2011
  3. Li, L., Shoji, W., Oshima, H., Obinata, M., Fukumoto, M., Kanno, N., Crucial role of peroxiredoxin III in placental antioxidant defense of mice, FEBS Lett., 582, p2431-2434, 2008
  4. Shoji, W. and Sato-Maeda, M., Application of heat shock promoter in transgenic zebrafish, Dev Growth Differ, 50, p401-406, 2008
  5. Sato-Maeda, M., Obinata, M., and Shoji, W., Position Fine-Tuning of Caudal Primary Motor Neurons in Zebrafish Spinal Cord, , Development, 135, p323-332, 2008
  6. Tanaka, H., Maeda, R., Shoji, W., Wada, H.,, Masai, I., Shiraki, T., Kobayashi, K., Nakayama, R., and Okamoto H., Novel mutations affecting axon guidance in zebrafish and a role for plexin signalling in the guidance of trigeminal and facial nerve axons., Development, 134, p3259-3269, 2007
  7. Li, L., Shoji, W., Kaifu, T., Takai, T., Takano, H., Nishimura, N., Aoki, Y., Takahashi, R., Goto, S., and Obinata M., Increased Susceptibility of MER5 (peroxiredoxin III) Knockout Mice to LPS-induced Oxidative Stress. Biochem Biophys Res Commun., 355 p715-721, 2007
  8. Sato-Maeda, M., Tawarayama, H., Obinata, M., Kuwada, J.Y., Shoji, W., Sema3a1 guides spinal motor axons in a cell- and stage-specific manner in zebrafish., Development, 133 p937-947, 2006
  9. Wolman, M. A., Liu, Y., Tawarayama, H., Shoji, W., and Halloran, M. C. Repulsion and Attraction of Axons by Sema3D are Mediated by Different Neuropilins in vivo, J Neurosci, 24 p8428-8435, 2004
  10. Yoshida, M., Inoue, T., Shoji, W., Ikawa, S., and Obinata, M., Reporter gene stimulation by MIDA1 through its DnaJ homology region, Biochem Biophys Res Commun., 324 p326-332, 2004
  11. Ober, E.A., Olofsson, B., Makinen, T., Jin, S.W., Shoji, W., Koh, G.Y., Alitalo, K., Stainier D.Y.,. Vegfc is required for vascular development and endoderm morphogenesis in zebrafish., EMBO Rep. 1 p78-84, 2004
  12. Liu, Y., Berndt, J., Su, F., Tawarayama, H., Shoji, W., Kuwada, J. Y. and Halloran, M. C., Semaphorin3D guides retinal axons along the dorsal-ventral axis of the tectum., J Neurosci., 24 p310-318, 2004
  13. Oyaizu, T., Okada, Y., Shoji, W., Matsumura, Y., Shimada, K., Sado, T., Sato, M. and Kondo, T., Reduction of recipient macrophages by gadolinium chloride prevents development of obliterative airway disease in a rat model of heterotopic tracheal transplantation, Transplantation, 76 p1214-1220 2003
  14. Shoji, W., Isogai, S., Sato-Maeda M., Obinata M., and Kuwada, J. Y., Semaphorin 3A1 regulates angioblast migration and vascular development in zebrafish embryos, Development, 130 p3227-3236, 2003
  15. Xiao, T., Shoji, W., Zhou, W., Su, F., and Kuwada, J.Y. Transmembrane Sema4E guides branchiomotor axons to their targets in zebrafish, J Neurosci. 23 p4190-4198, 2003
  16. Inoue, T., Shoji, W., Obinata, M. An Id-associated protein, MIDA1, is a sequence specific DNA binding protein with novel DNA binding properties. Gene to Cells, 5 p699-709, 2000
  17. Halloran, M. C., Sato-Maeda, M., Warren, J. T., Su, F., Lele, Z., Krone, P. H., Kuwada, J. Y., Shoji, W., Laser-induced gene expression in specific cells of transgenic zebrafish. Development, 127 p1953-1960, 2000

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