Institute of Development, Aging and Cancer, Tohoku University


Division of Geriatric Pharmacotherapy

Professor Takashi OHRUI, MD

About Division of Geriatric Pharmacotherapy
In Japan, the population of aged people is rapidly increasing. In general, older people have multiple organ failure including kidney and liver which are quite important for determining the serum levels of various drugs. In this division, we attempt to elucidate the relationship between drug use and drug toxicity in elderly frail subjects and to educate medical students and young medical doctors to use proper drugs for older frail patients. Furthermore, we attempt to discover a pleiotropic effect (novel action) in already employed drugs in elderly subjects.


  1. Kanda A, Yanai M, Suzuki T, Ohrui T and Sasaki H. Nocturnal wheeze in asthmatic patients. Chest 2000, 118:278.
  2. Ohrui T, Takahashi H, Ebihara S, Matsui T, Nakayama K and Sasaki H. Influenza A virus infection and pulmonary microthromboembolism. Tohoku J Exp Med 2000, 192:81-86.
  3. Ohrui T, Zayasu K, Satoh E, Matsui T, Sekizawa K and Sasaki H. Pulmonary tuberculosis and serum IgE. Clin Exp Immunol 2000, 122:13-15.
  4. Nakayama K, Monma M, Fukushima T, Ohrui T and Sasaki H. Tuberculin responses and risk of pneumonia in immobile elderly patients. Thorax 2000, 55:867-869.
  5. Ishizuka S, Yanai M, Yamaya M, Ohrui T, Sekizawa K and Sasaki H. Cough syncope treated with imidapril in an elderly patient with dysphagia. Chest 2000, 118:279.
  6. Sato E, Ohrui T, Matsui T, Arai H and Sasaki H. Folate deficiency and risk of pneumonia in the elderly. J Am Geriatr Soc 2001, 49:1739-1741.
  7. Yamaya M, Yanai M, Ohrui T, Arai H, Sekizawa K and Sasaki H. Antithrombotic therapy for prevention of pneumonia. J Am Geriatr Soc 2001, 49:687-688.
  8. Wada H, Nakajoh K, Satoh-Nakagawa T, Suzuki T, Ohrui T, Arai H and Sasaki H. Risk factors of aspiration pneumonia in Alzheimer’s disease patients. Gerontology 2001, 47:271-227.
  9. Jia YX, Li JQ, Matsui T, Yamaya M, Ohrui T, Sekizawa K and Sasaki H. Neurochemical regulation of swallowing reflex in guinea pigs. Geriatr Gerontol Internat 2001, 1:56-61.
  10. Ohrui T, Higuchi M, Kanda A, Matsui T, Sato E and Sasaki H. A patient with exacerbation of idiopathic pulmonary fibrosis which was resolved probably due to the coexisting hyperbilirubinemia? Tohoku J Exp Med 2001, 193:245-249.
  11. Yamaya M, Yanai M, Ohrui T, Arai H and Sasaki H. Interventions to prevent pneumonia among older adults. J Am Geriatr Soc 2001, 49:85-90.(Review).
  12. Nakayama K, Shinkawa M, Ohrui T, Hirai H and Sasaki H. Interferon-gamma responses to mycobacterial antigens in Heaf-positive children. Lancet 2002, 360:1335.
  13. Ohara Y, Ohrui T, Morikawa T and Sasaki H. Parental attitudes towards passive smoking in Japan. Lancet 2002, 359:1159.
  14. Yasuda H, Yamaya M, Yanai M, Ohrui T and Sasaki H. Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases. Thorax 2002, 57:779-783.
  15. Li JQ, Jia YX, Yamaya M, Arai H, Ohrui T, Sekizawa K and Sasaki H. Neurochemical regulation of cough response to capsaicin in guinea-pigs. Auton Autacoid Pharmacol 2002, 22:57-63.
  16. Ohrui T, Arai H, Ichinose M, Matsui T, Yamaya M and Sasaki H. Relationship between asthma severity and progression of Alzheimer’s disease. Thorax 2002, 57:561.
  17. Yoneyama T, Yoshida M, Ohrui T, Mukaiyama H, Okamoto H, Hoshiba K, Ihara S, Yanagisawa S, Ariumi S, Morita T, Mizuno Y, Ohsawa T, Akagawa Y, Hashimoto K, Sasaki H and Members of the Oral Care Working Group. Oral care reduces pneumonia of elderly patients in nursing homes. J Am Geriatr Soc 2002, 50:430-433.
  18. Nakamura M, Matsui T, Ohrui T, Kida K, Yamaya M and Sasaki H. Gender crossover of lung function. Geriatr Gerontol Internat 2002, 2:115-118.
  19. Matsui T, Yamaya M, Ohrui T, Arai H and Sasaki H. Sitting position to prevent aspiration in bed-ridden patients. Gerontology 2002, 48:194- 195.
  20. Ebihara T, Yamaya M, Ohrui T, Arai H and Sasaki H. Comparison of disabled older people in the USA and Japan. Geriatr Gerontol Internat 2002, 2:53-56.
  21. Wang HD, Yamaya M, Okinaga S, Jia YX, Kamanaka M, Takahashi H, Guo LY, Ohrui T and Sasaki H. Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats. Am J Respir Crit Care Med 2002, 165:406- 411.
  22. Shinkawa M, Yamaya M, Ohrui T, Arai H, Sasaki H. Depression in older people. Geriatr Gerontol Internat 2002, 2:215-216.
  23. Sasaki H, Yamaya M, Ohrui T, Kubo H, Ebihara S and Arai H. Characteristics of respiratory diseases in older people. Japanese Medical Association Journal 2002, 45: 231-236.
  24. Ohrui T, Namima T, Yamaya M, Sato T, Matsui T and Sasaki H. Risk of prostate cancer in the Japanese elderly asthmatics. J Am Geriatr Soc 2002, 50:202.
  25. Yamaya M, Ohrui T, Kubo H, Ebihara S, Arai H and Sasaki H. Prevention of respiratory infections in the elderly. Geriatr Gerontol Internat 2002, 2:115-121.(Review)
  26. Fujii M, Ohrui T, Sato T, Sato-Nakagawa T, Sato N, Sasaki H. Green tea for decubitus in bedridden patients. Geriatr Gerontol Internat 2003, 3:208-211.
  27. Kosaka Y, Satoh-Nakagawa T, Ohrui T, Yamaya M, Arai H, Sasaki H. Tube feeding in terminal care. Geriatr Gerontol Internat 2003, 3:172-174.
  28. Ohrui T, Yasuda H, Yamaya M, Matsui T, Sasaki H. Transient relief of asthma symptoms during jaundice: a possible beneficial role of bilirubin. Tohoku J Exp Med 2003, 199:193-196.
  29. Ohrui T, Kubo H and Sasaki H. Care for the older people. Intern Med 2003, 42:932-940.(Review)
  30. Ohrui T, Tomita N, Sato-Nakagawa T, Matsui T, Maruyama M, Niwa K, Arai H, Sasaki H. Effects of brain-penetrating ACE inhibitors on Alzheimer’s disease progression. Neurology 2004;63:1324-1325.
  31. Ohrui T, Matsui T, He M, Ebihara S, Sasaki H. Relation between retirement and subsequent health status in highly educational older man. J Am Geriatr Soc 2004;52:2145-2147.
  32. Horiuchi H, Matsuzawa Y, Mabuchi H, Itakura H, Sasaki J, Yokoyama M, Ishikawa Y, Yokoyama S, Mori S, Ohrui T, Akishita M, Hayashi T, Yamane K, Egusa G, Kita T. Strategy for treating elderly Japanese with hypercholesterolemia. Geriatr Gerontol Internat 2004;4:151-156.
  33. Chiba H, Ohrui T, Matsui T, Fukushima T, Sasaki H. Benefits of pneumococcal vaccination for bedridden patients. J Am Geriatr Soc 52:1410, 2004.
  34. Ohrui T. Interventions to prevent pneumonia in older adults. Geriatr Gerontol Internat 2004, 4:S92-S95.
  35. Ohrui T, Yamada M, Kubo H, Sasaki H. Survival rates between males and females. Geriatr Gerontol Internat 2004, 4:68-70.
  36. Fujii M, Yamaya M, Ohrui T, Arai H, Sasaki H. Inter-anal stool bag for the bedridden elderly with pressure ulcer. Geriatr Gerontol Internat 2004, 4:120-122.
  37. Kanda A, Ebihara S, Yasuda H, Ohrui T, Sasaki T, Sasaki H. A combinatorial therapy for pneumonia in elderly people. J Am Geriatr Soc 2004, 52:846-847.
  38. Furukawa E, Ohrui T, Yamaya M, Suzuki T, Nakasato H, Sasaki T, Kanda A, Yasuda H, Nishimura H, Sasaki H. Human airway submucosal glands augment eosinophil chemotaxis during rhinovirus infection. Clin Exp Allergy 2004, 34:704-711.
  39. Ohrui T, Matsui T, Yamaya M, Arai H, Ebihara S, Maruyama M, Sasaki H. ACE inhibitors and risk of Alzheimer’s disease in Japan. J Am Geriatr Soc 2004, 52:649-650.
  40. Ohrui T, Matsui T, Yamaya M, Kubo H, Arai H, Sasaki H. A new therapy for Alzheimer’s disease. Geriatr Gerontol Internat 2004, 4:123-125.
  41. He M, Ohrui T, Azumi M, Ida S, Sasaki H. Depressed involuntary swallowing and risk of pneumonia. J Am Geriatr Soc 2004, 52:1032-1033.
  42. Takahashi H, Ohrui T, Ebihara S, Yamada M, Sasaki H. Effect of gefitinib (ZD1839) on metastatic brain tumour. Lung Cancer 2004, 43:371-372.
  43. Ebihara S, Okazaki T, Ebihara T, Ohrui T, Yamaya M, Asada M, Yasuda H, Yamazaki M, Seki M, Toida I. Molecular differentiation of Mycobacterium Tuberculosis Complex on the basis of genomic deletions. Res Adv in Microbiology 2005;5:35-45.
  44. Maruyama M, Ishizawa K, Tomita N, Nemoto M, Yasuda H, Ebihara S, Ohrui T, Seki T, Iwasaki K, Okamura N, Higuchi M, Yoshida H, Kudo Y, Arai H, Sasaki H. Lithium therapy and cerebrospinal fluid biomarker levels in Alzheimer’s disease. Geriatr Gerontol Internat. 2005; 5:298-300.
  45. Ohrui T, Tanaka K, Chiba K, Matsui T, Tsuji I, Arai H, Sasaki H. Cognitive decline in patients with long-term domiciliary oxygen therapy. Tohoku J Exp Med 2005, 206:347-352.
  46. Ueda H, Yamada T, Ohrui T, Ebihara S, Kuraishi M, Kobayashi Y, Tamura M, Shimizu A, He M, Sasaki H. Correction of maxillary occlusal plane relieves persistent headache and shoulder stiffness. Tohoku J Exp Med 2005, 205,319-325.
  47. Ohrui T, He M, Tomita N, Sasaki H. Homicides of disabled older persons by their caregivers in Japan. J Am Geriatr Soc 2005, 53:553-554.
  48. Arai T, Sekizawa K, Ohrui T, Fujiwara H, Yoshimi N, Matsuoka H, Sasaki H. ACE inhibitors and protection against pneumonia in elderly patients with stroke. Neurology 2005, 64:573-574.
  49. Yamada M, Ohrui T, Asada M, Ishizawa K, Ebihara S, Arai H, Sasaki H. Acarbose attenuates hypoglycemia from dumping syndrome in an elderly man with gastrectomy. J Am Geriatr Soc 2005, 53:358-359.
  50. Morishima Y, Sekizawa K, Ohrui T, Sasaki H. ACE inhibitor-induced cough: lessons from animal models. ACUTE AND CHRONIC COUGH. Edited by Redington AE and Morice AH. Taylor & Francis group, Boca Raton 2005 Chapter 5, pp 81-103.
  51. Ohrui T. Preventive strategies for aspiration pneumonia in elderly disabled persons. Tohoku J Exp Med 2005, 207:3-12. (Review)
  52. Ebihara T, Ebihara S, Watando A, Okazaki T, Asada M, Ohrui T, Yamaya M, Arai H. Effects of menthol on the triggering of the swallowing reflex in elderly patients with dysphagia. Br J Clin Pharmacol 2006;62:369-371.
  53. Ohrui T, Matsui T, Yoshida M, Yoneyama T, Adachi M, Akagawa Y, He M, Yamaya M, Arai H, Sasaki H. Dental status and mortality in institutionalized elderly people. Geriatr Gerontol Internat 2006;6:101- 108.
  54. Ohara Y, Ohrui T, Morikawa T, He M, Yasuda H, Yamaya M, Sasaki H. Exhaled carbon monoxide levels in school-age children with episodic asthma. Pediatr Pulmonol 2006;41:470-474.
  55. Yasuda H, Okinaga S, Yamaya M, Ohrui T, Higuchi M, Shinkawa M, Itabashi S, Nakayama K, Shibahara S, Sasaki H. Association of susceptibility to the development of pneumonia in older Japanese population with the haem oxygenase-1 gene promoter polymorphism. J Med Genet 2006;43:e17.
  56. Ohrui T, Sasaki H. Aspiration Pneumonia. Principles & Practice of Geriatric Medicine 4th Agreement and Instructions. John Wiley & Sons, Ltd. Chichester 2006 Chapter 60, pp 685-692.
  57. He M, Ohrui T, Maruyama M, Tomita N, Higuchi M, Nakayama K, Furukawa K, Arai H. ACE activity in CSF of patients with mild cognitive impairment and Alzheimer’s disease. Neurology 2006;67:1309-1310.
  58. He M, Ohrui T, Ebihara T, Ebihara S, Sasaki H, Arai H. Mosapride citrate prolongs survival in stroke patients with gastrostomy. J Am Geriatr Soc 2007;55:142-143.
  59. Ebihara T, Ebihara S, Ida S, Ohrui T, Yasuda H, Sasaki H, Arai H. Acid and swallowing reflex. Geriatr Gerontol Internat 2007;7:94-95.
  60. Monma Y, Kato S, Iwasaki K, Ohrui T, Nakagawa-Sato T, Higuchi S, Ozaki S, Kaneko N, Seki T, Nakayama K, Furukawa K and Arai H. A pilot study of Banxia Houpu Tang, a traditional chinise medicine, for reducing pneumonia risk in older adults with dementia. J Am Geriatr Soc 2007;55: 2035-2040.
  61. Ohara Y, Ohrui T, Ebihara S, Ebihara T, Sasaki H and Arai H. Accidental carbon monoxide poisoning at home in Japan. Pediatric. Plum. 2007;42:853
  62. Numasaki M, Ohrui T, Sato A,He M, Arai H. Congenital tracheal stenosis and an anomalous origin of the right upper lobe bronchus. Lancet 2008, 371:1526.
  63. Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yokote K, Nomura H, Umegaki H, Iguchi A; Japan CDM group. Importance of lipid levels in elderly diabetic individuals:baseline characteristics and 1 year survey of cardiovascular events. Circ J 2008, 72: 218-225.
  64. Me M, Ohrui T, Arai H. Homicides of frail older persons by their caregivers in Japan. J Am Geriatr Soc 2009, 57:173-174.
  65. Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yokote K, Nomura H, Umegaki H, Iguchi A;on behalf of Japan CDM group. Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages. Diabetes Care 2009, 32:1221-1223.
  66. Sasaki T, Nakayama K, Yasuda H, Yoshida M, Asamura T, Ohrui T, Arai H, Araya J, Kuwano K, Yamaya M. A randomized, single-blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patients. J Am Geriatr Soc 2009, 57:1453-1457.
  67. Asamura T, Ohrui T, Une K, Furukawa K, Arai H. Centrally active ACEIs and cognitive decline. Arch Intern Med 2010, 170:107-108.
  68. Asamura T, Ohrui T, Nakayama K, He M, Yamasaki M, Ebihara T, Ebihara S, Furukawa K, Arai H. Low serum 1,25-dihydroxyvitamin D level and risk of respiratory infections in institutionalized older people. Gerontology 2010, 56:542-543.
  69. Une K, Takei YA, Tomita N, Asamura T, Ohrui T, Furukawa K, Arai H. Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer’s disease. Eur J Neurol 2011, 18 :1006-1009.
  70. Suzuki M, Uwano C, Ohrui T, Arai H. Shelter acquired pneumonia after a catastrophic earthquake in Japan. J Am Geriatr Soc (in press)

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