Institute of Development, Aging and Cancer, Tohoku University

Research

Seminars and Symposia

IDAC Seminar, 26 August 2016

Secretariat, Alumni Association, IDAC
Date Friday,26 August 2016, 17:00~
Room Seminar-shitsu 1, IDAC Research building 7F
Title The proteasome: destruction for life
Speaker Shigeo MURATA
Affiliation Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences,The University of Tokyo
Person-in-charge Hiroki SEKINE Dept. Gene Expression Regulation・ext8553
Abstract The proteasome is an essential intracellular proteolytic enzyme complex that degrades ubiquitinated proteins in eukaryotes. Increase or decrease in the proteasome activity has been shown to be associated with the pathogenesis of human diseases such as malignancies, inflammation, neurodegeneration, and aging. Thus, understanding the mechanisms that regulate the proteasome in mammals is of importance. In this talk, I will present our recent work regarding qualitative and quantitative regulation of the proteasome and their biological consequence.