Institute of Development, Aging and Cancer, Tohoku University

Research

Seminars and Symposia

IDAC Seminar, 18 May 2016

Secretariat, Alumni Association, IDAC
Date Monday,18 May 2016, 17:00~
Room Seminar-shitsu 1, IDAC Research building 7F
Title Disruption of redox signaling in cancer: the role of Nrf2 in cancer development
Speaker Aikseng Ooi
Affiliation College of Pharmacy, University of Arizona
Person-in-charge Hozumi Motohashi (Department of Gene Expression Regulation ext.8550)
Abstract The NRF2 transcription factor is the main regulator of cellular redox balance. Upon activation NRF2 promotes the expression of genes involved in xenobiotic and energy metabolisms, which facilitate the removal of electrophiles and neutralization of radical oxygen species, thereby restoring cellular redox balance. NRF2 is primarily regulated through its interactions with a protein known as KEAP1 (Kelch-like ECH-associated protein 1), a substrate adaptor protein for a CUL3-dependent ubiquitin ligase complex that ubiquitylates NRF2 for degradation. KEAP1 serves as a cellular electrophile sensor, whereby its surface cysteine residues are amenable to covalent modifications by various electrophiles. These modifications prevent KEAP1 mediated NRF2 ubiquitylation, leading to the accumulation and activation of NRF2. NRF2 activation is canonically accepted as a protection mechanism against malignant transformation. However recent studies unveiled an overrepresentation of somatic gain-of-function NRF2 mutations and somatic loss-of-function KEAP1 mutations in various cancer types. Collectively, these mutations drive a sustained NRF2 activation phenotype, suggesting that NRF2 activation may play a role in cancer development and progression. We provide a data-driven model of the role of NRF2 activation in carcinogenesis in both hereditary and sporadic cancers.