Institute of Development, Aging and Cancer, Tohoku University

Research

Seminars and Symposia

IDAC Seminar,15 May 2015

Secretariat, Alumni Association, IDAC
Date Friday,15 May 2015, 16:00~
Room Seminar-shitsu 1, IDAC Research building 7F
Title An alternative pluripotent state confers interspecies chimaeric competency
Speaker Daiji OKAMURA, Ph.D.
Affiliation Department of Advanced Bioscience, Faculty of Agriculture, Kinki University
Person-in-charge Kentaro Mochizukii Cell Resource Center for Biomedical Research ext. 8572
Abstract Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.

References:
Wu1st, Okamura1st, et al., (2015) Nature, in press.