Seminars and Symposia
IDAC Seminar,15 May 2015
|Secretariat, Alumni Association, IDAC|
|Date||Friday,15 May 2015, 16:00～|
|Room||Seminar-shitsu 1, IDAC Research building 7F|
|Title||An alternative pluripotent state confers interspecies chimaeric competency|
|Speaker||Daiji OKAMURA, Ph.D.|
|Affiliation||Department of Advanced Bioscience, Faculty of Agriculture, Kinki University|
|Person-in-charge||Kentaro Mochizukii Cell Resource Center for Biomedical Research ext. 8572|
|Abstract||Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.
Wu1st, Okamura1st, et al., (2015) Nature, in press.