Institute of Development, Aging and Cancer, Tohoku University

Research

Seminars and Symposia

IDAC Seminar, 23 July 2014

Secretariat, Alumni Association, IDAC
Date Wednesday,23 July 2014, 17:30~
Room Seminar-shitsu 1, IDAC Research building 7F
Title Identification of an inhibitor of AXL kinase to induce epithelial differentiation of human lung tissue-derived progenitor cells.
Speaker Naoya, Fujino
Affiliation Department of Advanced Preventive Medicine for Infectious Disease. Tohoku University Graduate School of Medicine
Person-in-charge Toshiyuki TAKAI Dept. Experimental Immunology (ex:8501)
Person-in-charge Differentiation of tissue-specific stem/progenitor cells has a role in homeostasis and repair. We previously isolated progenitor cells from adult human lung tissues, which had the ability to generate alveolar epithelial type II (ATII) cells (Fujino N, et al. Lab Invest 2011;91:363). However molecular mechanisms underlying the progenitor cell differentiation remain poorly understood. To address this question, we carried out a phenotypic screen using a small molecule library consisting of stem cell modulators and a diverse set of kinase inhibitors. We identified an inhibitor of AXL receptor tyrosine kinase, which drove the lung progenitor cells towards ATII cells via mesenchymal-to-epithelial transition. Our study reveals that AXL kinase acts as a barrier in the epithelial differentiation of human lung progenitor cells.