Institute of Development, Aging and Cancer, Tohoku University

Research

Seminars and Symposia

IDAC Seminar, 25 September 2013

Secretariat, Alumni Association, IDAC
Date Wednesday, 25 September 2013, 13:00~
Room Smart Aging Research Building International Conference Room
Title Notch signaling coordinates the spatial patters of lung epithelial cell types
Speaker Mitsuru Morimoto
Affiliation RIKEN Center for Developmental Biology, Laboratory for Lung
Development, Team Leader
Person-in-charge Yusuke Watanabei Dept. Developmental Neurobiology
(ex:8596)
Abstract The lung is a vital respiratory organ that is developed with organized branching formation and specialized-cell differentiation throughout embryogenesis. The most of the airway branching morphogenesis takes place at E12.0-16.5. During this time period, it is thought that the terminal buds contain a population of multi-potent epithelial progenitors. As the bronchial tree extends, descendants of these cells give rise to lineage-restricted progenitors in the conducting airways. Evidence demonstrating the importance of Notch signaling in the developing respiratory system is rapidly growing. We have been interested in a future of Notch signaling that alternatively determines a cell fate with inhibits the other cell fate. To disclose the mechanism by which the balance of lung epithelial cells is determined, we investigated the role for Notch signaling in lung development. We conducted genetic ablation of Notch receptors and RBPj in developing lung epithelium. The results from these analyses indicated that two different Notch signalings regulate the balance among three lung epithelial cell types; Clara, ciliated and Neuroendocrine cell.