Institute of Development, Aging and Cancer, Tohoku University

About

Dept. Nuclear Medicine and Radiology

Professor Yasuyuki TAKI
Senior Assistant Professor Tatsushi MUTOH
Assistant Professor Mitsunari ABE
Assistant Professor Yasuko TATEWAKI
Guest Instructor Tatsuo YAMAGUCHI
Guest Instructor Shigeo KINOMURA
Guest Instructor Kentaro INOUE
Guest Instructor Yukio ODANO
Guest Instructor Kazuhiro NAKAMURA
Guest Instructor Yuji TAKANO
Research Associate Hideo SHIMOMUA
Homepage of This Laboratory

Now we confront a super aging society in Japan. In the situation, it is important to preserve our cognitive function for entire life by preventing us from pathological brain aging. To perform the aim, we have built a large brain magnetic resonance imaging (MRI) database from around 3,000 subjects aged from five to 80 in order to reveal how brain develops and ages. We have also collected several cognitive functions, lifestyle such as eating and sleeping habits, and genetic data. Using the database, we have revealed normal brain development and aging, and also have revealed what factors affect brain development and aging. These findings help understanding the mechanism of brain development and aging as well as performing differential diagnosis or diagnosis at an early stage of several diseases/disorders such as autism and Alzheimer’s disease.


(Click for larger image.)
Figure 1 Longitudinal changes in the gray matter ratio between baseline and follow up. a, male subjects, b, female subjects (adapted from Taki, et al. Neurobiology of Aging. 2009;in press).

(Click for larger image.)
Figure 2 Gray matter regions that show significant negative (red scale) and positive (blue scale) correlations with BMI in men in cross-sectional VBM analysis (adapted from Taki, et al. Obesity. 2008;16:119-124)

Publication List
  1. Mutoh T, Kazumata K, Yokoyama Y, Ishikawa T, Taki Y, Terasaka S, Houkin K "Comparison of postoperative volume status and hemodynamics between surgical clipping and endovascular coiling in patients after subarachnoid hemorrhage" Journal of Neurosurgical Anesthesiology, 27:7-15, 2015
  2. Nakagawa S, Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Kotozaki Y, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R "Comprehensive neural networks for guilty feelings in young adults" NeuroImage, 105: 248-256, 2015
  3. Takeuchi H, Taki Y, Sekiguchi A, Hashizume H, Nouchi R, Sassa Y, Kotozaki Y, Miyauchi CM, Yokoyama R , Iizuka K, Nakagawa S, Nagase T, Kunitoki K, Kawashima R "Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults" Human Brain Mapping, in press.
  4. Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R "The impact of television viewing on brain structures: Cross-sectional and longitudinal analyses" Cerebral Cortex, in press
  5. Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R "Working memory training impacts the mean diffusivity in the dopaminergic system" Brain Structure and Function, in press
  6. Sekiguchi A, Kotozaki Y, Sugiura M, Nouchi R, Takeuchi H, Hanawa S, Nakagawa S, Miyauch CM, Araki T, Sakuma A, Taki Y, Kawashima R "Resilience after 3/11: Structural brain changes 1 year after the Japanese Earthquake" Molecular Psychiatry, in press.
  7. Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R "The structure of the amygdala associates with human sexual permissiveness: evidence from voxel-based morphometry" Human Brain Mapping, in press
  8. Hashimoto T, Takeuchi H, Taki Y, Yokota S, Hashizume H, Asano K, Asano M, Sassa Y, Nouchi R, Kawashima R "Increased Posterior Hippocampal Volumes in Children with Lower Increase in Body Mass Index: A 3-Year Longitudinal MRI Study." Developmental Neuroscience, 37, 153-160, 2015.
  9. Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R "The impact of parent–child interaction on brain structures: Cross-sectional and longitudinal analyses" Journal of Neuroscience, in press
  10. Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Sassa Y, Kawashima R "Brain structures in the sciences and humanities" Brain Structure and Function, in press
  11. Takeuchi H, Tomita H, Taki Y, Kikuchi Y, Ono C, Yu Z, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Sassa Y, Kawashima R "Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele" Neuroimage, in press.
  12. Hashimura N, Mutoh T, Matsuda K, Matsumoto K "Evaluation and management of plaque protrusion or thrombus following carotid artery stenting" Neurologia medico-chirurgica, 55:149-155, 2015
  13. Yokoyama R, Nozawa T, Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Hanihara M, Sassa Y, Kawashima R "Regional Gray Matter Density Associated with Cognitive Reflectivity–Impulsivity: Evidence from Voxel-Based Morphometry" PLoS ONE 10(3): e0122666, 2014.
  14. Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sassa Y, Sekiguchi A, Kotozaki Y, Nakagwa S, Nagase T, Miyauch CM, Kawashima R "Associations among imaging measures (2): The association between gray matter concentration and task-induced activation changes" Human Brain Mapping, Jan;35(1):185-98, 2014.
  15. Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R "White matter microstructural changes as vulnerability factors and acquired signs of post-earthquake distress" PLoS ONE, 9(1): e83967, 2014.
  16. Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R "Regional gray matter volume is associated with empathizing and systemizing in young adults" PLoS ONE, 9(1): e84782, 2014.
  17. Sekiguchi A, Kotozaki Y, Sugiura M, Nouchi R, Takeuchi H, Hanawa S, Nakagawa S, Miyauchi CM, Araki T, Sakuma A, Taki Y, Kawashima R "Long-term effects of post-earthquake distress on brain microstructural changes" BioMed Research International, 2014, 180468, 2014.
  18. Yokoyama R, Nozawa T, Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Kunitoki K, Hanihara M, Sassa Y, Kawashima R "Association between gray matter volume in the caudate nucleus and financial extravagance: findings from voxel-based morphometry" Neuroscience Letters, 563:28-32, 2014.
  19. Nouchi R, Taki Y, Takeuchi H, Sekiguchi A, Hashizume H, Nozawa T, Nouchi H, Kawashima R "Four weeks combination exercise training improved executive functions, episodic memory and processing speed in healthy elderly people: Evidence from a randomized controlled trial" AGE, 36(2), 787–799, 2014.
  20. Sumiyoshi A, Taki Y, Nonaka H, Takeuchi H, Kawashima R "Regional gray matter volume increases following 7 days of voluntary wheel running exercise: A longitudinal VBM study in rats" NeuroImage, 98, 82-90, 2014.
  21. Mutoh T, Kazumata K, Terasaka S, Taki Y, Suzuki A, Ishikawa T "Early-intensive versus minimally-invasive approach to postoperative hemodynamic management after subarachnoid hemorrhage" Stroke, 45:1280-1284, 2014.
  22. Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Hashizume H, Nakagawa S, Kunitoki K, Sassa Y, Kawashima R "Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry" Brain Structure and Function, 219(1):71–83, 2014.
  23. Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sassa Y, Sekiguchi A, Kotozaki Y, Nakagawa S, Nagase T, Miyauchi CM, Kawashima R "Anatomical correlates of quality of life: Evidence from voxel-based morphometry" Human Brain Mapping, 35(5):1834–1846, 2014.
  24. Takeuchi H, Taki Y, Nouchi R, Sekiguchi A, Hashizume H, Sassa Y, Kotozaki Y, Miyauchi CM, Yokoyama R, Iizuka K, Nakagawa S, Nagase T, Kunitoki K, Kawashima R "Association between resting-state functional connectivity and empathizing/systemizing" Neuroimage, 99(1):312–322, 2014.
  25. Nakagawa S, Sugiura M, Sekiguchi A, Kotozaki Y, Araki T, Hanawa S, Miyauchi CM, Sakuma A, Kawashima R "Fatigue and relating to others 3 months after the 2011 Great East Japan Earthquake" Psychiatry Research, 2014;218(3):324-328
  26. Sugiura M, Yomogida Y, Mano Y, Sassa Y, Toshimune K, Sekiguchi A, Kawashima R "From social-signal detection to higher social cognition: an fMRI approach" Social Cognitive and Affective Neuroscience, Sep; 9(9): 1303-9, 2014.
  27. Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R "Effects of Multitasking-Training on Gray Matter Structure and Resting State Neural Mechanisms" Human Brain Mapping, 35(8):3646-3660, 2014.
  28. Mutoh T, Kazumata K, Terasaka S, Taki Y, Suzuki A, Ishikawa T "Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage" Critical Care, 18:482, 2014.
  29. Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Hashizume H, Sassa Y, Kawashima R "Creativity measured by divergent thinking is associated with two axes of autistic characteristics" Frontiers in Psychology, 5:921, 2014
  30. Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R "Working memory training improves emotional states of healthy individuals" Frontiers in Systems Neuroscience, 8:200, 2014.
  31. Hashizume H, Taki Y, Sassa Y, Thyreau B, Asano M, Asano K, Takeuchi H, Nouchi R, Kotozaki Y, Jeong H, Sugiura M, Kawashima R "Developmental changes in brain activation involved in the production of novel speech sounds in children" Human Brain Mapping, 35(8):4079-4089, 2014.
  32. Kotozaki Y, Takeuchi H, Sekiguchi A, Yamamoto Y, Shinada T, Araki T, Takahashi K, Taki Y, Ogino T, Kiguchi M, Kawashima R "Biofeedback-based training for stress management in daily hassles: An intervention study" Brain and Behavior, 4(4):566-79.2014.
  33. Asano M, Taki Y, Hashizume H, Takeuchi H, Thyreau B, Sassa Y, Asano K, Kawashima R "Correlations between brain structures and study time at home in healthy children: A longitudinal analysis" Brain and Behavior, 4(6): 801–811, 2014.

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