Institute of Development, Aging and Cancer, Tohoku University

About

Dept. Metabolism

Professor Tokuo YAMAMOTO

The Department of metabolism, established in 2011 at IDAC, is now focused on the metabolic regulation of lipids and carbohydrates during aging. Based on the previous studies, we are studying the regulation of lipids and carbohydrate metabolism mediated by wnt proteins.


Publication

  1. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J. Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.
  2. SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation. Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J. J Biol Chem. 2007 Jun 29;282(26):19052-61. Epub 2007 Apr 4. 
  3. Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y. Diabetes. 2007 Jan;56(1):24-33.
  4. SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J. J Biol Chem. 2005 Nov 11;280(45):37669-80. Epub 2005 Sep 7.
  5. Deficiency of the very low-density lipoprotein (VLDL) receptors in streptozotocin-induced diabetic rats: insulin dependency of the VLDL receptor. Iwasaki T, Takahashi S, Takahashi M, Zenimaru Y, Kujiraoka T, Ishihara M, Nagano M, Suzuki J, Miyamori I, Naiki H, Sakai J, Fujino T, Miller NE, Yamamoto TT, Hattori H. Endocrinology. 2005 Aug;146(8):3286-94. Epub 2005 May 5.
  6. A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. Yamamoto J, Ikeda Y, Iguchi H, Fujino T, Tanaka T, Asaba H, Iwasaki S, Ioka RX, Kaneko IW, Magoori K, Takahashi S, Mori T, Sakaue H, Kodama T, Yanagisawa M, Yamamoto TT, Ito S, Sakai J. J Biol Chem. 2004 Apr 23;279(17):16954-62. Epub 2004 Feb 10. 
  7. The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues. Takahashi S, Sakai J, Fujino T, Miyamori I, Yamamoto TT. Mol Cell Biochem. 2003 Jun;248(1-2):121-7. Review.
  8. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34. Epub 2002 Dec 30. 
  9. Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. Magoori K, Kang MJ, Ito MR, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT. J Biol Chem. 2003 Mar 28;278(13):11331-6. Epub 2002 Dec 31.
  10. Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1. Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT. J Biol Chem. 2003 Feb 28;278(9):7344-9. Epub 2002 Dec 20.
  11. Etiological significance of apolipoprotein E mutations in lipoprotein glomerulopathy. Saito T, Ishigaki Y, Oikawa S, Yamamoto TT. Trends Cardiovasc Med. 2002 Feb;12(2):67-70. Review.
  12. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT. J Biol Chem. 2001 Sep 21;276(38):35961-6. Epub 2001 Jul 24.
  13. Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1. Ikeda Y, Yamamoto J, Okamura M, Fujino T, Takahashi S, Takeuchi K, Osborne TF, Yamamoto TT, Ito S, Sakai J. J Biol Chem. 2001 Sep 7;276(36):34259-69. Epub 2001 Jul 2.
  14. Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. Fujino T, Kondo J, Ishikawa M, Morikawa K, Yamamoto TT. J Biol Chem. 2001 Apr 6;276(14):11420-6. Epub 2001 Jan 9.
  15. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. Yamashita Y, Kumabe T, Cho YY, Watanabe M, Kawagishi J, Yoshimoto T, Fujino T, Kang MJ, Yamamoto TT. Oncogene. 2000 Nov 30;19(51):5919-25.
  16. Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. Ishigaki Y, Oikawa S, Suzuki T, Usui S, Magoori K, Kim DH, Suzuki H, Sasaki J, Sasano H, Okazaki M, Toyota T, Saito T, Yamamoto TT. J Biol Chem. 2000 Oct 6;275(40):31269-73.

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