Institute of Development, Aging and Cancer, Tohoku University

About

Div. Cognitive Neuroscience

Professor(Additional) Ryuta KAWASHIMA
Associate Professor Hikaru TAKEUCHI
Assistant Professor Susumu YOKOTA
Assistant Professor Teruo HASHIMOTO
Homepage of This Laboratory

In this division, one of our main research topics is how the brain develops and matures in healthy children as well as children with cognitive impairment(s) from the viewpoint of brain structure and function using magnetic resonance imaging (MRI) in relation to their lifestyle by a longitudinal cohort study. We have already revealed that several lifestyle choices, such as sleeping habits and breakfast staples, affect gray matter volume and some cognitive functions in healthy children.

Now we are performing longitudinal studies for brain development with collecting not only brain MRI but also genetic factors on both healthy and children with cognitive impairment(s). We believe our investigations would help (1) clarify the mechanisms of brain development, (2) early diagnosis of several disorders such as autistic spectrum disorders, and (3) develop new teaching and learning system in children.

図1
Fig.1 The associations among daily habit, brain and cognitive functions
in children
図2
Fig.2 Schematics of research on children with developmental disorder.

Publication

  1. 1. Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R. The impact of parent-child interaction on brain structures: Cross-sectional and longitudinal analyses. Journal of Neuroscience, 35(5):2233-2245.
  2. Hashimoto T, Takeuchi H, Taki Y, Yokota S, Hashizume H, Asano K, Asano M, Sassa Y, Nouchi R, Kawashima R. Increased Posterior Hippocampal Volumes in Children with Lower Increase in Body Mass Index: A 3-Year Longitudinal MRI Study. Developmental Neuroscience, in press
  3. Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R. The impact of television viewing on brain structures: Cross-sectional and longitudinal analyses. Cerebral Cortex, in press
  4. Hashizume H, Taki Y, Sassa Y, Thyreau B, Asano M, Asano K, Takeuchi H, Nouchi R, Kotozaki Y, Jeong H, Sugiura M, Kawashima R. Developmental changes in brain activation involved in the production of novel speech sounds in children. Human Brain Mapping, 35(8):4079-4089, 2014
  5. Yokota S, Taki Y, Hashizume H, Sassa Y, Thyreau B, Tanaka M, Kawashima R. Neural correlates of deception in social contexts in normally developing children. Frontier in Human Neuroscience, May 17;7:206, 2013
  6. Taki Y, Thyreau B, Hashizume H, Sassa Y, Takeuchi H, Wu K, Kotozaki Y, Nouchi R, Asano M, Asano K, Fukuda H, Kawashima R. Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region-of-interest analyses in 246 healthy children. Human Brain Mapping, Aug;34(8):1842-56, 2013
  7. Taki Y, Hashizume H, Thyreau B, Sassa Y, Takeuchi H, Wu K, Kotozaki Y, Nouchi R, Asano M, Asano K, Fukuda H, Kawashima R. Linear and curvilinear correlations of brain gray matter volume and density with age using voxel-based morphometry with the Akaike information criterion in 291 healthy children. Human Brain Mapping, Aug; 34(8):1857-71, 2013
  8. Taki Y, Hashizume H, Sassa Y, Takeuchi H, Asano M, Asano K, Kotozaki Y, Nouchi R, Kai W, Fukuda H, Kawashima R. Correlation among body height, intelligence, and brain gray matter volume in healthy children. NeuroImage, 59: 1023-1027, 2012
  9. Taki Y, Thyreau B, Hashizume H, Sassa Y, Takeuchi H, Wu K, Kotozaki Y, Nouchi R, Asano M, Asano K, Fukuda H, Kawashima R. Sleep duration during weekdays affects hippocampal gray matter volume in healthy children. NeuroImage, 60: 471-475, 2012
  10. Taki Y, Hashizume H, Sassa Y, Takeuchi H, Wu K, Asano M, Asano K, Fukuda H, Kawashima R. Correlation between gray matter density-adjusted brain perfusion and age using brain MR images of 202 healthy children. Human Brain Mapping, 32, 1973-1985, 2011

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