Professor

Hiroshi FUKUDA

Associate Professor

Yasuyuki TAKI

Associate Professor

Kentaro INOUE

Assistant Professor

Ryoi GOTO

Assistant Professor

Ken OKADA

Post Doctor

Kai WU

Major two goal of the research in this department is to establish a clinical preventive medicine for age-related brain diseases and control of cancers. Fundamental approaches to the goal are to use mostly advanced imaging modalities, such as PET, SPECT and MRI. More specifically the following projects are going on: (1) Age-related change of brain function studied with PET and SPECT, (2) Construction of Japanese brain MRI database and its analyses, (3) Identification of risk factors on brain aging, (4) Investigation of pathogenesis in degenerative brain disease, such as dementia. Based on the results from these study, consultation and medication to patients with are performing in outpatient clinic.

We firstly developed a PET for cancer diagnosis base on increased metabolism of cancers and are continuing experimental and clinical studies on PET in oncology. The achievements contributed much to the initiation of reimbursement of the study by the government. Our department (Nuclear Medicine) is in charge for PET studies, which was installed at University Hospital in this year.

As described above, the researches on brain aging and cancer diagnosis are going on, which coincide with the urgent request from the rapidly aging society.

(Click for larger image.)

Figure 1　Longitudinal changes in the gray matter ratio between baseline and follow up. a, male subjects, b, female subjects (adapted from Taki, et al. Neurobiology of Aging. 2009;in press).

(Click for larger image.)

Figure 2　Gray matter regions that show significant negative (red scale) and positive (blue scale) correlations with BMI in men in cross-sectional VBM analysis (adapted from Taki, et al. Obesity. 2008;16:119-124)

Publication List

2011年

1. Taki Y, Kinomura S, Sato K, Goto R, Kawashima R, Fukuda H. A longitudinal study of gray matter volume decline with age and modifying factors. Neurobiol Aging　32: 907-915, 2011.
2. Taki Y, Kinomura S, Sato K, Goto R, Kai Wu. Kawashima R, Fukuda H. Correlation between baseline regional gray matter volume and global gray matter volume decline rate. NeuroImage 54: 743-749, 2011.
3. Taki Y, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H. Correlation between gray/white matter volume and cognition in healthy elderly people. Brain and Cognition 75: 170-176, 2011.
4. Minamimoto R, Senda M, Terauchi T, Jinnouchi S, Inoue T, Iinuma T, Inoue T, Ito K, Iwata H, Uno K, Okku S, Oguchi K, Tsukamoto E, Nakashima R, Nishizawa S, Fukuda H, Murano T, Yoshida T. Analysis of various malignant neoplasms detected by FDG-PET cancer screening programa: based on a Japanese Nationwide Survey. Ann Nucl Med 25: 45-54, 2011.
5. Taki Y, Kinomura S, Sato K, Goto R, Kai Wu. Kawashima R, Fukuda H. Correlation between degree of white matter hyperintensities and global gray matter volume decline rate. Neuroradiology, 53(6):397-403,2011.
6. Taki Y, Hashizume H, Sassa Y, Takeuchi H, Wu K, Asano M, Asano K, Fukuda H, Kawashima R. Correlation between gray matter density-adjusted brain perfusion and age using brain MR images of 202 healthy children. Human Brain Mapping, 2011 (in press).
7. Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, Nishio Y, Sawada Y,Takahashi S, Fukuda H, Itoyama Y, Mori E. Illusory misidentification and cortical hypometabolism in Parkinson’s disease. Movement Disorder 26(5):837-843, 2011.
8. Mitamura A, Kaneta T, Miyata G, Takanami K, Hiraide3 T, Fukuda H, Takahashi S,Satomi S. Positive correlation between tumor uptake on FDG PET and energy　expenditure of patients with esophageal cancer. Ann Nucl Med 25(4):241-6,2011.
9. Baba T, Takeda A, Kikuchi A, Nishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, Mori E, Takahashi S, Fukuda H, and Itoyama Y. Research Article. Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease. Movement Disorders, 26(4):621-628, 2011.

2010年

1. Takanami K, Hiraide T, Kaneta T, Hayashi H, Unno M, Fujishima F, Fukuda H, Yamada S, and Takahashi S. FDG PET/CT findings in malignant intraductal papillary mucinous neoplasm of the bile ducts A case report. Clin Nucl Med 35(2): 83-85, 2010 Feb.
2. Kikuchi A, Takeda A, Okamura N, Tashiro M, Hasegawa T, Furumoto S, Kobayashi M, Sugeno N, Baba T, Miki Y, Mori F, Wakabayashi K, Funaki Y, Iwata R, Takahashi S, Fukuda H, Arai H, Kudo Y, Yanai K and Itoyama Y. In vivo visualization of α-synuclein deposition by carbon-11-labelled 2-[2-（2-dimethylaminothiazol-5-yl）etheny]-6-［2-（fluoro）ethoxy］ benzoxazole positron emission tomography in multiple system atrophy. Brain 133: 1772-1778, 2010.
3. Taki Y, Hashizume H, Sassa Y, Takeuchi H, Asano M, Asano K, Kawashima R Breakfast Staple Types Affect Brain Gray Matter Volume and Cognitive Function in Healthy Children. PLoS ONE, 5(12): e15213, 1-8, 2010.
4. Watanuki S, Tashiro M, Miyake M, Ishikawa Y, Itoh M, Yanai K, Sakemi Y, Fukuda H, Ishii K. Long-term performance evaluation of positron emissiontomography: analysis and proposal of a maintenance protocol for long-term utilization. Ann Nucl Med 24: 461-468, 2010.
5. Asumi M, Yamaguchi T, Saito K, Kodama S, Miyazawa H, Matsui H, Suzuki E, Fukuda H, Sone H. Are serum cholesterol levels associated with silent brain infacrts? The Seiryo Clinic Study. Atherosclerosis. 210(2):674-7, 2010.

2009年

1. Hosokai Y, Nishio Y, Hirayama K, Takeda A, Ishioka T, Sawada Y, Suzuki K, Itoyama Y, Takahashi S, Fukuda H and Mori E. Distinct Patterns of Regional Cerebral Glucose Metabolism in Parkinson’s Disease with and without Mild Cognitive Impairment. Movement Disorders、24２４：854-862, 2009.
2. Abe N, Fujii T, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Nishio Y, Suzuki K, Itoyama Y, Takahashi S, Fukuda H and Mori E. Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behavior. Brain. 132: 1386-1395, 2009.
3. Tateishi U, Hosono A, Makimoto A, Nakamoto Y, Kaneta T, Fukuda H, Murakami K, Terauchi T, Suga T, Inoue T, Kim E.E. Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma. Ann Nucl Med 23(2):155-161, 2009.
4. Inoue K, Okada K, Taki Y, Goto R, Kinomura S, Fukuda H. 18FDG uptake associated with CT density on PET/CT in lungs with and without chronic interstitial lung diseases. Ann Nucl Med 23(3): 277-281, 2009.
5. Kaneta T, Takahashi S, Fukuda H, Arisaka Y, Oriuchi N, Hayashi T, Fujii H, Terauchi T, Tateishi U, Kubota K, Hara T, Nakamoto Y, Kitajima K, Murakami K. Clinical significance of performing 18F-FDG PET on patients with gastrointestinal stromal tumors: a summary of a Japanese multicenter study. Ann Nucl Med. 23: 459-464, 2009.
6. Nakamoto Y, Togashi K, Kaneta T, Fukuda H, Nakajima K, Kitajima K, Murakami K, Fujii H, Satake M, Tateishi U, Kubota K and Senda M. Clinical valueof whole-body FDG-PET for recurrent gastric cancer: A multicenter study. Jpn J Clin Oncol. 39(5): 297-302, 2009.
7. Ogura T, Ito H, Hida K, Masuzuka T, Fukuda H, Hatazawa J. Measurementofcerebral blood flow by the autoradiographic method with N-isopropyl-4-〔I-123〕iodoamphetamine: comparison of radiopharmaceuticals marketed by different companies in Japan. Ann Nucl Med 23: 355-361, 2009.
8. Inoue K, Okada K, Kinomura S, Fukuda H. A bone marrow F-18 FDG uptake
   exceeding the liver uptake may indicate bone marrow hyperactivity. Ann Nucl Med 23: 643-649, 2009.
9. Lee E, Kinomura S, Meguro K, Akanuma K, Meguro M, Fukuda H. Confabulationson episodic and semantic memory questions are associated with differentneurological backgrounds in Alzheimer disease. Cog Behav Neurol 22(2): 81-88, 2009.
10. Takanami K, Kaneta T, Yamada S, Fukuda H, Takahashi S. F-18 FDG PET/CTfindings of primary carcinoma of the Fallopian tube. Clin Nucl Med 34(6): 377-8, 2009.
11. Kaneta T, Takanami K, Mitamura A, Hiraide T, Fukuda H, Yamada S, and Takahashi S. FDG accumulation in obturator herniation of the bladder mimickingmetastatic disease. Clin Nucl Med 34(6): 395-7, 2009.

2008年

1. Inoue K, Okada K, Taki Y, Goto R, Kinomura S, Kaneta T, Fukuda H. Increase of serum CA19-9 level without an evident lesion on conventional imaging is insufficient for justification of 18FDG-PET examination. Hepato-Gastroenterology. 55(81): 46-9, 2008 Jan-Feb.
2. Taki Y, Kinomura S, Sato K, Inoue K, Goto R, Okada K, Uchida S, Kawashima R and Fukuda H: Relationship between body mass index and gray matter volume in 1,428 healthy individuals. Obesity 16: 119-124, 2008.
3. Tashiro M, Fukuda H, Itoh M, Matsuzawa T and Yanai K: Molecular Imaging at Tohoku University: From Cancer to Neuroreceptors. Current Medical Imaging Reviews.8-13, 2008.　
4. Takanami K, Kaneta T, Tamada T, Yamada T, Higano S, Yamada S, Fukuda H, Takahashi S. Q fever with lymphadenopathy on F-18 FDG PET. Clin Nucl Med 33(6): 436-437, 2008.
5. Takanami K, Kaneta T, Yamada T, Kinomura S, Yamada S, Fukuda H, Takahashi S. FDG PET for esophageal cancer complicated by sarcoidosis mimicking mediastinal and hilar lymph node metastases: two case reports. Clin Nucl Med 33(4): 258-2612008.
6. Inoue K, Ito H, Uchida S, Taki Y, Kinomura S, Tsuji I, Sato S, Horie K, Kawashima R, Ito M, Fukuda H: Decrease in glucose metabolism in frontal cortex associated with deterioration of microstructure of corpus callosum measured by diffusion tensor imaging in healthy elderly. Human Brain Mapping. 29(4): 375-84, 2008.
7. Evans AC, Lee JM, Kim SI, Fukuda H, Kawashima R, He Y, Jiang T, Kim JS, Chen Z, Im K, Lyttelton O, Lerch J, Singh V, Sato K, Taki Y, Goto R, Kinomura S, Mok K, Lee JK, Yoon U. Human Cortical Anatomical Networks Assessed by Structural MRI. Brain Imaging and Behavior 2: 289−299, 2008.