8th International Conference on
Functional Mapping of the Human Brain
June 2 - 6,2002, Sendai, JAPAN
Monday, June 3 PM
09:00-09:30
Keynote Lecture
Neural Computations and Neural Representations in Prefrontal Cortex: How Many Ways to Slice the Pie?
Suzanne Corkin MIT Cambridge, MA, U.S.A.
Progress toward understanding the computations and representations in prefrontal cortex demands the synthesis of information from several disciplines. Studies in monkeys and humans with discrete frontal-lobe lesions provide evidence about specific cognitive deficits, and about alterations in mood, personality, and arousal that may influence cognitive performance. The lesion approach provides important information about the brain circuits that are necessary for particular cognitive functions. Advanced structural imaging techniques, by revealing more subtle anatomical deficits, provide us with new tools to uncover precise brain-behavior relations. Functional imaging identifies the brain areas that are recruited in the performance of a particular cognitive task, and can leverage this knowledge to elucidate experimentally the component cognitive processes that underlie complex task performance. Information that is unobtainable in humans comes from single-unit recordings in awake, behaving monkeys, which inform us about neuronal activity during the performance of successive cognitive operations over time, and with spatial resolution yet unthinkable in human studies. Models that attempt to explain the function(s) of prefrontal cortex must take into account the information from these diverse disciplines. Recent attempts to do so have resulted in an apparent polarization of the field, with advocates of neural quasi-equipotentiality and adaptability on one side (Miller, Cohen, Duncan, Dehaene, Fuster), and proponents of multiple process-specific (or material-specific) specializations on the other (Petrides, Goldman-Rakic, Gabrieli, Wagner, Johnson, DfEsposito, Postle). Some of the questions that have grown out of this debate include: Is it possible to characterize prefrontal specialization in terms of specific cognitive operations? and Can lesion, imaging, and physiology data be explained in terms of the adaptation to task requirements of a general prefrontal mechanism? This talk will address these issues and other equally contentious points.